TY - JOUR
T1 - Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis
AU - Piet, Jurgen R.
AU - Geldhoff, Madelijn
AU - van Schaik, Barbera D. C.
AU - Brouwer, Matthijs C.
AU - Valls Seron, Mercedes
AU - Jakobs, Marja E.
AU - Schipper, Kim
AU - Pannekoek, Yvonne
AU - Zwinderman, Aeilko H.
AU - van der Poll, Tom
AU - van Kampen, Antoine H. C.
AU - Baas, Frank
AU - van der Ende, Arie
AU - van de Beek, Diederik
PY - 2014
Y1 - 2014
N2 - Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis genes to be associated with outcome in patients with pneumococcal meningitis. Pneumococci harboring these genes show increased growth in human blood and cerebrospinal fluid (CSF). Mouse models of meningitis and pneumonia showed that pneumococcal strains without arginine biosynthesis genes were attenuated in growth or cleared, from lung, blood and CSF. Thus, S. pneumoniae arginine synthesis genes promote growth and virulence in invasive pneumococcal disease
AB - Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis genes to be associated with outcome in patients with pneumococcal meningitis. Pneumococci harboring these genes show increased growth in human blood and cerebrospinal fluid (CSF). Mouse models of meningitis and pneumonia showed that pneumococcal strains without arginine biosynthesis genes were attenuated in growth or cleared, from lung, blood and CSF. Thus, S. pneumoniae arginine synthesis genes promote growth and virulence in invasive pneumococcal disease
U2 - 10.1093/infdis/jit818
DO - 10.1093/infdis/jit818
M3 - Article
C2 - 24338350
SN - 0022-1899
VL - 209
SP - 1781
EP - 1791
JO - Journal of infectious diseases
JF - Journal of infectious diseases
IS - 11
ER -