Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease

V. I. Kwa; H. C. Weinstein; E. F. Posthumus Meyjes; E. A. van Royen; L. J. Bour; P. N. Verhoeff; B. W. Ongerboer de Visser

doi:10.1016/0006-3223(93)90308-Z

Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease

V. I. Kwa
, H. C. Weinstein
, E. F. Posthumus Meyjes
, E. A. van Royen
, L. J. Bour
, P. N. Verhoeff
, B. W. Ongerboer de Visser

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietal-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demonstrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietal regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism

Original language	English
Pages (from-to)	100-107
Journal	Biological psychiatry
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/0006-3223(93)90308-Z
Publication status	Published - 1993

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@article{4110abf38c184bad8e4c021ba59604e8,

title = "Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease",

abstract = "99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietal-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demonstrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietal regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism",

author = "Kwa, \{V. I.\} and Weinstein, \{H. C.\} and \{Posthumus Meyjes\}, \{E. F.\} and \{van Royen\}, \{E. A.\} and Bour, \{L. J.\} and Verhoeff, \{P. N.\} and \{Ongerboer de Visser\}, \{B. W.\}",

year = "1993",

doi = "10.1016/0006-3223(93)90308-Z",

language = "English",

volume = "33",

pages = "100--107",

journal = "Biological psychiatry",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "2",

}

TY - JOUR

T1 - Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease

AU - Kwa, V. I.

AU - Weinstein, H. C.

AU - Posthumus Meyjes, E. F.

AU - van Royen, E. A.

AU - Bour, L. J.

AU - Verhoeff, P. N.

AU - Ongerboer de Visser, B. W.

PY - 1993

Y1 - 1993

N2 - 99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietal-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demonstrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietal regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism

AB - 99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietal-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demonstrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietal regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism

U2 - 10.1016/0006-3223(93)90308-Z

DO - 10.1016/0006-3223(93)90308-Z

M3 - Article

C2 - 8439599

SN - 0006-3223

VL - 33

SP - 100

EP - 107

JO - Biological psychiatry

JF - Biological psychiatry

IS - 2

ER -

Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease

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