TY - JOUR
T1 - Sex differences in brain atrophy in dementia with Lewy bodies
AU - Oltra, Javier
AU - Habich, Annegret
AU - Schwarz, Christopher G.
AU - Nedelska, Zuzana
AU - Przybelski, Scott A.
AU - Inguanzo, Anna
AU - Diaz-Galvan, Patricia
AU - Lowe, Val J.
AU - Oppedal, Ketil
AU - Gonzalez, Maria C.
AU - Philippi, Nathalie
AU - Blanc, Frederic
AU - Barkhof, Frederik
AU - Lemstra, Afina W.
AU - Hort, Jakub
AU - Padovani, Alessandro
AU - Rektorova, Irena
AU - Bonanni, Laura
AU - Massa, Federico
AU - Kramberger, Milica G.
AU - Taylor, John-Paul
AU - Snædal, Jon G.
AU - Walker, Zuzana
AU - Antonini, Angelo
AU - Dierks, Thomas
AU - Segura, Barbara
AU - Junque, Carme
AU - Westman, Eric
AU - Boeve, Bradley F.
AU - Aarsland, Dag
AU - Kantarci, Kejal
AU - Ferreira, Daniel
N1 - Funding Information:
This work was supported by the National Institutes of Health (NHS) (U01‐NS100620, P50‐AG016574, U01‐AG006786, R37‐AG011378, R01‐AG041851, R01‐AG040042, C06‐RR018898, and R01‐NS080820), Foundation Dr Corinne Schuler, the Mangurian Foundation for Lewy Body Research, the Elsie and Marvin Dekelboum Family Foundation, the Little Family Foundation, the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program, the Western Norway Regional Health Authority, the Swedish Foundation for Strategic Research (SSF), the Swedish Research Council (VR), Karolinska Institutet travel grants, Center for Innovative Medicine (CIMED), the Swedish Brain Foundation (Hjärnfonden), the Swedish Alzheimer's Foundation (Alzheimerfonden), ALF Medicine, the Swedish Dementia Foundation (Demensförbundet), the Foundation for Geriatric Diseases at Karolinska Institutet, and the Projet Hospitalier de Recherche Clinique (PHRC, IDCRB 2012‐A00992‐41) and Fondation Université de Strasbourg. This paper represents independent research [part] funded by the National Institute for Health Research (NIHR) Biomedical Research Center at South London and Maudsley NHS Foundation Trust and King's College London to D.A. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. The work was also supported by the Ministry of Health of the Czech Republic (Grant NU20‐04‐00294) and LX22NPO5107 (MEYS): Funded by European Union – Next Generation EU. We acknowledge the contribution of the core facility MAFIL of CEITEC supported by the MEYS CR (LM2018129 Czech‐BioImaging). J.O. was supported by a 2018 fellowship from the Spanish Ministry of Science, Innovation and Universities and co‐financed by the European Social Fund (PRE2018‐086675). Z.N. is supported by The Grant Agency of Charles University (Grant PRIMUS 22/MED/011). The sponsors played no role in the study design, in the collection, analysis, and interpretation of data, in the writing of the report, or in the decision to submit the article for publication. K.O. is funded by the Western Norway Regional Health Authority by Postdoc Grant 912152. D.A. is a Royal Society Wolfson Research Merit Award Holder and would like to thank the Wolfson Foundation and the Royal Society for their support. E.W. and D.F. are supported by the Swedish Foundation for Strategic Research (SSF), the Strategic Research Program in Neuroscience at Karolinska Institutet (StratNeuro), the Swedish Research Council (VR), the Åke Wiberg Foundation, Hjärnfonden, Alzheimerfonden, Demensfonden, and Birgitta och Sten Westerberg.
Publisher Copyright:
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023
Y1 - 2023
N2 - INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS: We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males). RESULTS: We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex. DISCUSSION: We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75. Highlights: Male DLB patients had higher odds for frontal atrophy on radiological visual rating scales. Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods. Sex differences in gray matter measures in DLB tended to disappear with increasing age.
AB - INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS: We included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males). RESULTS: We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex. DISCUSSION: We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75. Highlights: Male DLB patients had higher odds for frontal atrophy on radiological visual rating scales. Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods. Sex differences in gray matter measures in DLB tended to disappear with increasing age.
KW - atrophy
KW - dementia with Lewy bodies
KW - magnetic resonance imaging
KW - sex differences
UR - https://www.scopus.com/pages/publications/85180259158
U2 - 10.1002/alz.13571
DO - 10.1002/alz.13571
M3 - Article
C2 - 38131463
SN - 1552-5260
JO - Alzheimer s & dementia
JF - Alzheimer s & dementia
ER -