Serum alkaline phosphatase is a prognostic marker in bone metastatic disease of the extremity

Quirina C. B. S. Thio; Aditya V. Karhade; Emily Notman; Kevin A. Raskin; Santiago Lozano Calderón; Marco L. Ferrone; Jos A. M. Bramer; Joseph H. Schwab

doi:10.1016/j.jor.2020.08.008

Serum alkaline phosphatase is a prognostic marker in bone metastatic disease of the extremity

Quirina C. B. S. Thio^*
, Aditya V. Karhade
, Emily Notman
, Kevin A. Raskin
, Santiago Lozano Calderón
, Marco L. Ferrone
, Jos A. M. Bramer
, Joseph H. Schwab

^*Corresponding author for this work

Harvard University
University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: The purpose of this study was to determine the prognostic value of serum alkaline phosphatase for treatment decision making in metastatic bone disease. Methods: 1090 patients who underwent surgery for extremity metastatic disease were retrospectively identified at two tertiary care centers. The association between alkaline phosphatase and mortality was assessed by bivariate and multivariate analyses. Results: Three-month and one-year mortality rates were 305 (29%) and 639 (62%), respectively. Alkaline phosphatase was associated with mortality at both three months and one year. Conclusion: Serum alkaline phosphatase may be a useful marker in prognostic algorithms for patients with extremity metastatic disease.

Original language	English
Pages (from-to)	346-351
Number of pages	6
Journal	Journal of orthopaedics
Volume	22
DOIs	https://doi.org/10.1016/j.jor.2020.08.008
Publication status	Published - 1 Nov 2020

Keywords

Alkaline phosphatase
Biomarker
Bone metastasis
Prognostic factor
Survival

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10.1016/j.jor.2020.08.008

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title = "Serum alkaline phosphatase is a prognostic marker in bone metastatic disease of the extremity",

abstract = "Purpose: The purpose of this study was to determine the prognostic value of serum alkaline phosphatase for treatment decision making in metastatic bone disease. Methods: 1090 patients who underwent surgery for extremity metastatic disease were retrospectively identified at two tertiary care centers. The association between alkaline phosphatase and mortality was assessed by bivariate and multivariate analyses. Results: Three-month and one-year mortality rates were 305 (29\%) and 639 (62\%), respectively. Alkaline phosphatase was associated with mortality at both three months and one year. Conclusion: Serum alkaline phosphatase may be a useful marker in prognostic algorithms for patients with extremity metastatic disease.",

keywords = "Alkaline phosphatase, Biomarker, Bone metastasis, Prognostic factor, Survival",

author = "Thio, \{Quirina C. B. S.\} and Karhade, \{Aditya V.\} and Emily Notman and Raskin, \{Kevin A.\} and Calder{\'o}n, \{Santiago Lozano\} and Ferrone, \{Marco L.\} and Bramer, \{Jos A. M.\} and Schwab, \{Joseph H.\}",

year = "2020",

month = nov,

day = "1",

doi = "10.1016/j.jor.2020.08.008",

language = "English",

volume = "22",

pages = "346--351",

journal = "Journal of orthopaedics",

issn = "0972-978X",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Serum alkaline phosphatase is a prognostic marker in bone metastatic disease of the extremity

AU - Thio, Quirina C. B. S.

AU - Karhade, Aditya V.

AU - Notman, Emily

AU - Raskin, Kevin A.

AU - Calderón, Santiago Lozano

AU - Ferrone, Marco L.

AU - Bramer, Jos A. M.

AU - Schwab, Joseph H.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Purpose: The purpose of this study was to determine the prognostic value of serum alkaline phosphatase for treatment decision making in metastatic bone disease. Methods: 1090 patients who underwent surgery for extremity metastatic disease were retrospectively identified at two tertiary care centers. The association between alkaline phosphatase and mortality was assessed by bivariate and multivariate analyses. Results: Three-month and one-year mortality rates were 305 (29%) and 639 (62%), respectively. Alkaline phosphatase was associated with mortality at both three months and one year. Conclusion: Serum alkaline phosphatase may be a useful marker in prognostic algorithms for patients with extremity metastatic disease.

AB - Purpose: The purpose of this study was to determine the prognostic value of serum alkaline phosphatase for treatment decision making in metastatic bone disease. Methods: 1090 patients who underwent surgery for extremity metastatic disease were retrospectively identified at two tertiary care centers. The association between alkaline phosphatase and mortality was assessed by bivariate and multivariate analyses. Results: Three-month and one-year mortality rates were 305 (29%) and 639 (62%), respectively. Alkaline phosphatase was associated with mortality at both three months and one year. Conclusion: Serum alkaline phosphatase may be a useful marker in prognostic algorithms for patients with extremity metastatic disease.

KW - Alkaline phosphatase

KW - Biomarker

KW - Bone metastasis

KW - Prognostic factor

KW - Survival

UR - https://www.scopus.com/pages/publications/85089810966

U2 - 10.1016/j.jor.2020.08.008

DO - 10.1016/j.jor.2020.08.008

M3 - Article

C2 - 32921951

SN - 0972-978X

VL - 22

SP - 346

EP - 351

JO - Journal of orthopaedics

JF - Journal of orthopaedics

ER -

Serum alkaline phosphatase is a prognostic marker in bone metastatic disease of the extremity

Abstract

Keywords

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