Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine

B. M. de Jong; M. G. Feenstra; J. M. Ruijter; E. A. van Royen

doi:10.1016/0014-4886(89)90055-1

Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine

B. M. de Jong
, M. G. Feenstra
, J. M. Ruijter
, E. A. van Royen

Research output: Contribution to journal › Comment/Letter to the editor › Academic

Abstract

In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system

Original language	English
Pages (from-to)	297-299
Journal	Experimental neurology
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/0014-4886(89)90055-1
Publication status	Published - 1989

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@article{ed6a478fb96042a8aa80da7c1fff3fa5,

title = "Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine",

abstract = "In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system",

author = "\{de Jong\}, \{B. M.\} and Feenstra, \{M. G.\} and Ruijter, \{J. M.\} and \{van Royen\}, \{E. A.\}",

year = "1989",

doi = "10.1016/0014-4886(89)90055-1",

language = "English",

volume = "103",

pages = "297--299",

journal = "Experimental neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine

AU - de Jong, B. M.

AU - Feenstra, M. G.

AU - Ruijter, J. M.

AU - van Royen, E. A.

PY - 1989

Y1 - 1989

N2 - In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system

AB - In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system

U2 - 10.1016/0014-4886(89)90055-1

DO - 10.1016/0014-4886(89)90055-1

M3 - Comment/Letter to the editor

C2 - 2920796

SN - 0014-4886

VL - 103

SP - 297

EP - 299

JO - Experimental neurology

JF - Experimental neurology

IS - 3

ER -

Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine

Abstract

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