Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA

Richard J. Honeywell; Dzjemma Sarkisjan; Ietje Kathmann; Michael H. Kristensen; Godefridus J. Peters

doi:10.1080/15257770.2016.1216566

Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA

Richard J. Honeywell
, Dzjemma Sarkisjan
, Ietje Kathmann
, Michael H. Kristensen
, Godefridus J. Peters

Research output: Contribution to journal › Article › Academic › peer-review

27 Downloads (Pure)

Original language	English
Pages (from-to)	652-662
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	35
Issue number	10-12
DOIs	https://doi.org/10.1080/15257770.2016.1216566
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gemcitabine
difluorodeoxyuridine
incorporation into DNA
deoxycytidine kinase
thymidine kinase 2
cyclopentenylcytosine
fluorocyclopentenylcytosine
RX-3117

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10.1080/15257770.2016.1216566

Sensitive-liquid-chromatography-mass-spectrometry-lc-ms-assay-reveals-novel-insights-on-dna-methylation-and-incorporat.pdfFinal published version, 795 KBLicence: Taverne

Cite this

Honeywell, R. J., Sarkisjan, D., Kathmann, I., Kristensen, M. H., & Peters, G. J. (2016). Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA. Nucleosides, Nucleotides and Nucleic Acids, 35(10-12), 652-662. https://doi.org/10.1080/15257770.2016.1216566

Honeywell, Richard J. ; Sarkisjan, Dzjemma ; Kathmann, Ietje et al. / Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA. In: Nucleosides, Nucleotides and Nucleic Acids. 2016 ; Vol. 35, No. 10-12. pp. 652-662.

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title = "Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA",

keywords = "Gemcitabine, difluorodeoxyuridine, incorporation into DNA, deoxycytidine kinase, thymidine kinase 2, cyclopentenylcytosine, fluorocyclopentenylcytosine, RX-3117",

author = "Honeywell, \{Richard J.\} and Dzjemma Sarkisjan and Ietje Kathmann and Kristensen, \{Michael H.\} and Peters, \{Godefridus J.\}",

year = "2016",

doi = "10.1080/15257770.2016.1216566",

language = "English",

volume = "35",

pages = "652--662",

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Honeywell, RJ , Sarkisjan, D, Kathmann, I, Kristensen, MH & Peters, GJ 2016, 'Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA', Nucleosides, Nucleotides and Nucleic Acids, vol. 35, no. 10-12, pp. 652-662. https://doi.org/10.1080/15257770.2016.1216566

Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA. / Honeywell, Richard J.; Sarkisjan, Dzjemma; Kathmann, Ietje et al.
In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 35, No. 10-12, 2016, p. 652-662.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA

AU - Honeywell, Richard J.

AU - Sarkisjan, Dzjemma

AU - Kathmann, Ietje

AU - Kristensen, Michael H.

AU - Peters, Godefridus J.

PY - 2016

Y1 - 2016

KW - Gemcitabine

KW - difluorodeoxyuridine

KW - incorporation into DNA

KW - deoxycytidine kinase

KW - thymidine kinase 2

KW - cyclopentenylcytosine

KW - fluorocyclopentenylcytosine

KW - RX-3117

U2 - 10.1080/15257770.2016.1216566

DO - 10.1080/15257770.2016.1216566

M3 - Article

C2 - 27906622

SN - 1525-7770

VL - 35

SP - 652

EP - 662

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 10-12

ER -

Honeywell RJ , Sarkisjan D, Kathmann I, Kristensen MH, Peters GJ. Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA. Nucleosides, Nucleotides and Nucleic Acids. 2016;35(10-12):652-662. doi: 10.1080/15257770.2016.1216566