TY - JOUR
T1 - Search for HRV-parameters that detect a sympathetic shift in heart failure patients on beta-blocker treatment
AU - Zhang, Yanru
AU - de Peuter, Olav R.
AU - Kamphuisen, Pieter W.
AU - Karemaker, John M.
PY - 2013
Y1 - 2013
N2 - Background: A sympathetic shift in heart rate variability (HRV) from high to lower frequencies may be an early signal of deterioration in a monitored patient. Most chronic heart failure (CHF) patients receive (3-blockers. This tends to obscure HRV observation by increasing the fast variations. We tested which HRV parameters would still detect the change into a sympathetic state. Methods and results: beta-blocker (Carvedilol (R)) treated CHF patients underwent a protocol of 10 min supine rest, followed by 10 min active standing. CHF patients (NYHA Class 11-1V) n = 15, 10m/5f, mean age 58.4 years (47-72); healthy controls n = 29, 18m/11f, mean age 62.9 years (49-78). lnterbeat intervals (IBI) were extracted from the finger blood pressure wave (Nexfine (R)). Both linear and non-linear HRV analyses were applied that (1) might be able to differentiate patients from healthy controls under resting conditions and (2) detect the change into a sympathetic state in the present short recordings. Linear: mean-IBI, SD-IBI, root mean square of successive differences (rMSSD), pIBI-50 (the proportion of intervals that differs by more than 50 ms from the previous), LF, HF, and LE/HE ratio. Non-linear: Sample entropy (SampEn), Multiscale entropy (MSE), and derived: Multiscale variance (MSV) and Multiscale rMSSD (MSD). In the supine resting situation patients differed from controls by having higher HF and, consequently, lower LF/HE In addition their longer range (iota = 6 10) MSE was lower as well The sympathetic shift was, in controls, detected by mean-IBI, rMSSD, p1B1-50, and LF/HF, all going down; in CHF by mean-IBI, rMSSD, pIBI-50, and MSD (iota = 6 10) going down. MSD6-10 introduced here works as a band-pass filter favoring frequencies from 0.02 to 0.1 Hz. Conclusions: In beta-blocker treated CHF patients, traditional time domain analysis (mean-IBI, rMSSD, pIBI-50) and MSD6-10 provide the most useful information to detect a condition change
AB - Background: A sympathetic shift in heart rate variability (HRV) from high to lower frequencies may be an early signal of deterioration in a monitored patient. Most chronic heart failure (CHF) patients receive (3-blockers. This tends to obscure HRV observation by increasing the fast variations. We tested which HRV parameters would still detect the change into a sympathetic state. Methods and results: beta-blocker (Carvedilol (R)) treated CHF patients underwent a protocol of 10 min supine rest, followed by 10 min active standing. CHF patients (NYHA Class 11-1V) n = 15, 10m/5f, mean age 58.4 years (47-72); healthy controls n = 29, 18m/11f, mean age 62.9 years (49-78). lnterbeat intervals (IBI) were extracted from the finger blood pressure wave (Nexfine (R)). Both linear and non-linear HRV analyses were applied that (1) might be able to differentiate patients from healthy controls under resting conditions and (2) detect the change into a sympathetic state in the present short recordings. Linear: mean-IBI, SD-IBI, root mean square of successive differences (rMSSD), pIBI-50 (the proportion of intervals that differs by more than 50 ms from the previous), LF, HF, and LE/HE ratio. Non-linear: Sample entropy (SampEn), Multiscale entropy (MSE), and derived: Multiscale variance (MSV) and Multiscale rMSSD (MSD). In the supine resting situation patients differed from controls by having higher HF and, consequently, lower LF/HE In addition their longer range (iota = 6 10) MSE was lower as well The sympathetic shift was, in controls, detected by mean-IBI, rMSSD, p1B1-50, and LF/HF, all going down; in CHF by mean-IBI, rMSSD, pIBI-50, and MSD (iota = 6 10) going down. MSD6-10 introduced here works as a band-pass filter favoring frequencies from 0.02 to 0.1 Hz. Conclusions: In beta-blocker treated CHF patients, traditional time domain analysis (mean-IBI, rMSSD, pIBI-50) and MSD6-10 provide the most useful information to detect a condition change
U2 - 10.3389/fphys.2013.00081
DO - 10.3389/fphys.2013.00081
M3 - Article
C2 - 23596424
SN - 1664-042X
VL - 4
SP - 81
JO - Frontiers in physiology
JF - Frontiers in physiology
ER -