Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score

A S Meijnikman; C E M De Block; A Verrijken; I Mertens; B Corthouts; L F Van Gaal

doi:10.1016/j.jdiacomp.2016.05.004

Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score

A S Meijnikman
, C E M De Block
, A Verrijken
, I Mertens
, B Corthouts
, L F Van Gaal

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIM: To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status.

METHODS: In 651 overweight/obese subjects (M/F: 193/458, age 43±13 y, BMI 38.2±6.1kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and subcutaneous fat (SAT) were examined.

RESULTS: Exactly 50.4% were found to have prediabetes and 11.1% were newly diagnosed with type 2 diabetes (T2DM) (M/F=22.2/8.8%). Subjects without T2DM had a FINDRISC score of 11±3, those with pre-DM 13±4, and subjects with de novo T2DM 15±5. The aROC of the FINDRISC for detecting T2DM was 0.76 (95% CI 0.72-0.82), with 13 as cutoff point. The FINDRISC score correlated with VAT (r=0.34, p<0.001) and VAT/SAT ratio (r=0.39, p<0.001). The aROC of the FINDRISC to detect excess VAT was 0.79 (95%CI 0.72-0.84).

CONCLUSIONS: In a large group of overweight and obese subjects, 50.4% were found to have pre-DM and 11.1% were newly diagnosed with T2DM. The FINDRISC score increased with worsening of glucose tolerance status and proved to be an independent predictor of T2DM status, as did HOMA-B, HOMA-S and VAT. The FINDRISC can also function as a good tool to predict visceral obesity.

Original language	English
Pages (from-to)	1043-9
Number of pages	7
Journal	Journal of diabetes and its complications
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.jdiacomp.2016.05.004
Publication status	Published - Aug 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Diabetes Mellitus, Type 2/diagnosis
Female
Humans
Intra-Abdominal Fat
Male
Middle Aged
Obesity/complications
Overweight/complications
Subcutaneous Fat

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10.1016/j.jdiacomp.2016.05.004

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@article{3ba10bf978fa4d2d87bc4df9cbd757ed,

title = "Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score",

abstract = "AIM: To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status.METHODS: In 651 overweight/obese subjects (M/F: 193/458, age 43±13 y, BMI 38.2±6.1kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and subcutaneous fat (SAT) were examined.RESULTS: Exactly 50.4\% were found to have prediabetes and 11.1\% were newly diagnosed with type 2 diabetes (T2DM) (M/F=22.2/8.8\%). Subjects without T2DM had a FINDRISC score of 11±3, those with pre-DM 13±4, and subjects with de novo T2DM 15±5. The aROC of the FINDRISC for detecting T2DM was 0.76 (95\% CI 0.72-0.82), with 13 as cutoff point. The FINDRISC score correlated with VAT (r=0.34, p<0.001) and VAT/SAT ratio (r=0.39, p<0.001). The aROC of the FINDRISC to detect excess VAT was 0.79 (95\%CI 0.72-0.84).CONCLUSIONS: In a large group of overweight and obese subjects, 50.4\% were found to have pre-DM and 11.1\% were newly diagnosed with T2DM. The FINDRISC score increased with worsening of glucose tolerance status and proved to be an independent predictor of T2DM status, as did HOMA-B, HOMA-S and VAT. The FINDRISC can also function as a good tool to predict visceral obesity.",

keywords = "Adult, Diabetes Mellitus, Type 2/diagnosis, Female, Humans, Intra-Abdominal Fat, Male, Middle Aged, Obesity/complications, Overweight/complications, Subcutaneous Fat",

author = "Meijnikman, \{A S\} and \{De Block\}, \{C E M\} and A Verrijken and I Mertens and B Corthouts and \{Van Gaal\}, \{L F\}",

year = "2016",

month = aug,

doi = "10.1016/j.jdiacomp.2016.05.004",

language = "English",

volume = "30",

pages = "1043--9",

journal = "Journal of diabetes and its complications",

issn = "1056-8727",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score

AU - Meijnikman, A S

AU - De Block, C E M

AU - Verrijken, A

AU - Mertens, I

AU - Corthouts, B

AU - Van Gaal, L F

PY - 2016/8

Y1 - 2016/8

N2 - AIM: To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status.METHODS: In 651 overweight/obese subjects (M/F: 193/458, age 43±13 y, BMI 38.2±6.1kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and subcutaneous fat (SAT) were examined.RESULTS: Exactly 50.4% were found to have prediabetes and 11.1% were newly diagnosed with type 2 diabetes (T2DM) (M/F=22.2/8.8%). Subjects without T2DM had a FINDRISC score of 11±3, those with pre-DM 13±4, and subjects with de novo T2DM 15±5. The aROC of the FINDRISC for detecting T2DM was 0.76 (95% CI 0.72-0.82), with 13 as cutoff point. The FINDRISC score correlated with VAT (r=0.34, p<0.001) and VAT/SAT ratio (r=0.39, p<0.001). The aROC of the FINDRISC to detect excess VAT was 0.79 (95%CI 0.72-0.84).CONCLUSIONS: In a large group of overweight and obese subjects, 50.4% were found to have pre-DM and 11.1% were newly diagnosed with T2DM. The FINDRISC score increased with worsening of glucose tolerance status and proved to be an independent predictor of T2DM status, as did HOMA-B, HOMA-S and VAT. The FINDRISC can also function as a good tool to predict visceral obesity.

AB - AIM: To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status.METHODS: In 651 overweight/obese subjects (M/F: 193/458, age 43±13 y, BMI 38.2±6.1kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and subcutaneous fat (SAT) were examined.RESULTS: Exactly 50.4% were found to have prediabetes and 11.1% were newly diagnosed with type 2 diabetes (T2DM) (M/F=22.2/8.8%). Subjects without T2DM had a FINDRISC score of 11±3, those with pre-DM 13±4, and subjects with de novo T2DM 15±5. The aROC of the FINDRISC for detecting T2DM was 0.76 (95% CI 0.72-0.82), with 13 as cutoff point. The FINDRISC score correlated with VAT (r=0.34, p<0.001) and VAT/SAT ratio (r=0.39, p<0.001). The aROC of the FINDRISC to detect excess VAT was 0.79 (95%CI 0.72-0.84).CONCLUSIONS: In a large group of overweight and obese subjects, 50.4% were found to have pre-DM and 11.1% were newly diagnosed with T2DM. The FINDRISC score increased with worsening of glucose tolerance status and proved to be an independent predictor of T2DM status, as did HOMA-B, HOMA-S and VAT. The FINDRISC can also function as a good tool to predict visceral obesity.

KW - Adult

KW - Diabetes Mellitus, Type 2/diagnosis

KW - Female

KW - Humans

KW - Intra-Abdominal Fat

KW - Male

KW - Middle Aged

KW - Obesity/complications

KW - Overweight/complications

KW - Subcutaneous Fat

U2 - 10.1016/j.jdiacomp.2016.05.004

DO - 10.1016/j.jdiacomp.2016.05.004

M3 - Article

C2 - 27217020

SN - 1056-8727

VL - 30

SP - 1043

EP - 1049

JO - Journal of diabetes and its complications

JF - Journal of diabetes and its complications

IS - 6

ER -

Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score

Abstract

UN SDGs

Keywords

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