S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration

Alexi Nott; Justyna Nitarska; Jesse V. Veenvliet; Stephan Schacke; Alwin A.H.A. Derijck; Piotr Sirko; Christian Muchardt; R. Jeroen Pasterkamp; Marten P. Smidt; Antonella Riccio

doi:10.1073/pnas.1218126110

S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration

Alexi Nott
, Justyna Nitarska
, Jesse V. Veenvliet
, Stephan Schacke
, Alwin A.H.A. Derijck
, Piotr Sirko
, Christian Muchardt
, R. Jeroen Pasterkamp
, Marten P. Smidt
, Antonella Riccio^*

^*Corresponding author for this work

University College London
Utrecht University
University of Amsterdam
Institut Pasteur Paris

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.

Original language	English
Pages (from-to)	3113-3118
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	110
Issue number	8
DOIs	https://doi.org/10.1073/pnas.1218126110
Publication status	Published - 19 Feb 2013

Keywords

Neural development
Nitric oxide synthase
Polar morphology
Schizophrenia
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10.1073/pnas.1218126110

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Nott, A., Nitarska, J., Veenvliet, J. V., Schacke, S., Derijck, A. A. H. A., Sirko, P., Muchardt, C., Pasterkamp, R. J., Smidt, M. P., & Riccio, A. (2013). S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proceedings of the National Academy of Sciences of the United States of America, 110(8), 3113-3118. https://doi.org/10.1073/pnas.1218126110

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title = "S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration",

abstract = "Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.",

keywords = "Neural development, Nitric oxide synthase, Polar morphology, Schizophrenia, Transcription",

author = "Alexi Nott and Justyna Nitarska and Veenvliet, \{Jesse V.\} and Stephan Schacke and Derijck, \{Alwin A.H.A.\} and Piotr Sirko and Christian Muchardt and Pasterkamp, \{R. Jeroen\} and Smidt, \{Marten P.\} and Antonella Riccio",

year = "2013",

month = feb,

day = "19",

doi = "10.1073/pnas.1218126110",

language = "English",

volume = "110",

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journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Nott, A, Nitarska, J, Veenvliet, JV, Schacke, S, Derijck, AAHA, Sirko, P, Muchardt, C, Pasterkamp, RJ, Smidt, MP & Riccio, A 2013, 'S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 8, pp. 3113-3118. https://doi.org/10.1073/pnas.1218126110

S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. / Nott, Alexi; Nitarska, Justyna; Veenvliet, Jesse V. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 8, 19.02.2013, p. 3113-3118.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration

AU - Nott, Alexi

AU - Nitarska, Justyna

AU - Veenvliet, Jesse V.

AU - Schacke, Stephan

AU - Derijck, Alwin A.H.A.

AU - Sirko, Piotr

AU - Muchardt, Christian

AU - Pasterkamp, R. Jeroen

AU - Smidt, Marten P.

AU - Riccio, Antonella

PY - 2013/2/19

Y1 - 2013/2/19

N2 - Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.

AB - Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.

KW - Neural development

KW - Nitric oxide synthase

KW - Polar morphology

KW - Schizophrenia

KW - Transcription

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U2 - 10.1073/pnas.1218126110

DO - 10.1073/pnas.1218126110

M3 - Article

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SP - 3113

EP - 3118

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 8

ER -

S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration

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