Role of the quinone structure in the mitochondrial damage induced by antitumor anthracyclines. Comparison of adriamycin and 5-iminodaunorubicin

G. Pollakis; E. Goormaghtigh; J. M. Ruysschaert

doi:10.1016/0014-5793(82)80618-2

Role of the quinone structure in the mitochondrial damage induced by antitumor anthracyclines. Comparison of adriamycin and 5-iminodaunorubicin

G. Pollakis
, E. Goormaghtigh
, J. M. Ruysschaert

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Adriamycin cardiotoxicity has been correlated with a disturbance of heart mitochondrial functions. Here, 5-iminodaunorubicin was compared with adriamycin for its capability to interfere in the mitochondrial electron transport with subsequent membrane damaging. The results suggest that minor chemical modifications of the anthraquinone moiety of anthracycline glycoside drugs should be a promising way to decrease mitochondrial membrane damage induced by this class of antitumor drugs

Original language	English
Pages (from-to)	267-272
Journal	FEBS letters
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(82)80618-2
Publication status	Published - 1983

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title = "Role of the quinone structure in the mitochondrial damage induced by antitumor anthracyclines. Comparison of adriamycin and 5-iminodaunorubicin",

abstract = "Adriamycin cardiotoxicity has been correlated with a disturbance of heart mitochondrial functions. Here, 5-iminodaunorubicin was compared with adriamycin for its capability to interfere in the mitochondrial electron transport with subsequent membrane damaging. The results suggest that minor chemical modifications of the anthraquinone moiety of anthracycline glycoside drugs should be a promising way to decrease mitochondrial membrane damage induced by this class of antitumor drugs",

author = "G. Pollakis and E. Goormaghtigh and Ruysschaert, \{J. M.\}",

year = "1983",

doi = "10.1016/0014-5793(82)80618-2",

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T1 - Role of the quinone structure in the mitochondrial damage induced by antitumor anthracyclines. Comparison of adriamycin and 5-iminodaunorubicin

AU - Pollakis, G.

AU - Goormaghtigh, E.

AU - Ruysschaert, J. M.

PY - 1983

Y1 - 1983

N2 - Adriamycin cardiotoxicity has been correlated with a disturbance of heart mitochondrial functions. Here, 5-iminodaunorubicin was compared with adriamycin for its capability to interfere in the mitochondrial electron transport with subsequent membrane damaging. The results suggest that minor chemical modifications of the anthraquinone moiety of anthracycline glycoside drugs should be a promising way to decrease mitochondrial membrane damage induced by this class of antitumor drugs

AB - Adriamycin cardiotoxicity has been correlated with a disturbance of heart mitochondrial functions. Here, 5-iminodaunorubicin was compared with adriamycin for its capability to interfere in the mitochondrial electron transport with subsequent membrane damaging. The results suggest that minor chemical modifications of the anthraquinone moiety of anthracycline glycoside drugs should be a promising way to decrease mitochondrial membrane damage induced by this class of antitumor drugs

U2 - 10.1016/0014-5793(82)80618-2

DO - 10.1016/0014-5793(82)80618-2

M3 - Article

C2 - 6852236

SN - 0014-5793

VL - 155

SP - 267

EP - 272

JO - FEBS letters

JF - FEBS letters

IS - 2

ER -

Role of the quinone structure in the mitochondrial damage induced by antitumor anthracyclines. Comparison of adriamycin and 5-iminodaunorubicin

Abstract

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