Role of mast cells in colorectal cancer development, the jury is still out

J. Heijmans; N. V. Büller; V. Muncan; G. R. van den Brink

doi:10.1016/j.bbadis.2010.12.001

Role of mast cells in colorectal cancer development, the jury is still out

J. Heijmans
, N. V. Büller
, V. Muncan
, G. R. van den Brink

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

The link between inflammation and colorectal cancer development is becoming increasingly clear. It had long been recognized that patients with inflammatory bowel disease are at an increased risk of colon cancer. Evidence from experimental animals now also implicates the innate immune system in the development of sporadically occurring intestinal adenomas, the precursors to colorectal cancer. Here we discuss the interaction between the immune system and the adenoma to carcinoma sequence with a special emphasis on the role of mast cells which may play a key role in adenoma development. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2010 Elsevier B.V. All rights reserved

Original language	English
Pages (from-to)	9-13
Journal	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume	1822
Issue number	1
DOIs	https://doi.org/10.1016/j.bbadis.2010.12.001
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.bbadis.2010.12.001

Cite this

@article{31dbf79f6b204dfc9b8818be3053fe9c,

title = "Role of mast cells in colorectal cancer development, the jury is still out",

abstract = "The link between inflammation and colorectal cancer development is becoming increasingly clear. It had long been recognized that patients with inflammatory bowel disease are at an increased risk of colon cancer. Evidence from experimental animals now also implicates the innate immune system in the development of sporadically occurring intestinal adenomas, the precursors to colorectal cancer. Here we discuss the interaction between the immune system and the adenoma to carcinoma sequence with a special emphasis on the role of mast cells which may play a key role in adenoma development. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2010 Elsevier B.V. All rights reserved",

author = "J. Heijmans and B{\"u}ller, \{N. V.\} and V. Muncan and \{van den Brink\}, \{G. R.\}",

year = "2012",

doi = "10.1016/j.bbadis.2010.12.001",

language = "English",

volume = "1822",

pages = "9--13",

journal = "BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE",

issn = "0925-4439",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Role of mast cells in colorectal cancer development, the jury is still out

AU - Heijmans, J.

AU - Büller, N. V.

AU - Muncan, V.

AU - van den Brink, G. R.

PY - 2012

Y1 - 2012

N2 - The link between inflammation and colorectal cancer development is becoming increasingly clear. It had long been recognized that patients with inflammatory bowel disease are at an increased risk of colon cancer. Evidence from experimental animals now also implicates the innate immune system in the development of sporadically occurring intestinal adenomas, the precursors to colorectal cancer. Here we discuss the interaction between the immune system and the adenoma to carcinoma sequence with a special emphasis on the role of mast cells which may play a key role in adenoma development. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2010 Elsevier B.V. All rights reserved

AB - The link between inflammation and colorectal cancer development is becoming increasingly clear. It had long been recognized that patients with inflammatory bowel disease are at an increased risk of colon cancer. Evidence from experimental animals now also implicates the innate immune system in the development of sporadically occurring intestinal adenomas, the precursors to colorectal cancer. Here we discuss the interaction between the immune system and the adenoma to carcinoma sequence with a special emphasis on the role of mast cells which may play a key role in adenoma development. This article is part of a Special Issue entitled: Mast cells in inflammation. (C) 2010 Elsevier B.V. All rights reserved

U2 - 10.1016/j.bbadis.2010.12.001

DO - 10.1016/j.bbadis.2010.12.001

M3 - Review article

C2 - 21146606

SN - 0925-4439

VL - 1822

SP - 9

EP - 13

JO - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

JF - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

IS - 1

ER -

Role of mast cells in colorectal cancer development, the jury is still out

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this