Role of interleukin-8 in onset of the immune response in intravesical BCG therapy for superficial bladder cancer

E. C. de Boer; L. Somogyi; G. J. de Ruiter; T. M. de Reijke; K. H. Kurth; D. H. Schamhart

doi:10.1007/BF00941903

Role of interleukin-8 in onset of the immune response in intravesical BCG therapy for superficial bladder cancer

E. C. de Boer
, L. Somogyi
, G. J. de Ruiter
, T. M. de Reijke
, K. H. Kurth
, D. H. Schamhart

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In intravesical therapy for superficial bladder carcinoma urothelial cells may, through the production of cytokines, contribute to the bacillus Calmette-Guerin (BCG)-induced local immunological reaction and associated antitumor efficacy. The aim of this study was to investigate such a role for the neutrophil-attracting cytokine interleukin-8 (IL-8). The appearance of IL-8 in patients urine after BCG therapy was compared with BCG-induced IL-6 and IL-2 and the stability of IL-8 in urine was tested. Compared to IL-6 and IL-2, a rapid induction of IL-8 was observed, occurring after the first BCG instillation. Urinary IL-8 was highly stable, even after 24 h incubation at 37 degrees C. The IL-8 concentration after the first instillation seemed to be associated with subsequent development of an immune response. Consequently, IL-8 seems an attractive candidate for investigation of its prognostic value for a clinical response to BCG therapy

Original language	English
Pages (from-to)	31-34
Journal	Urological research
Volume	25
Issue number	1
DOIs	https://doi.org/10.1007/BF00941903
Publication status	Published - 1997

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title = "Role of interleukin-8 in onset of the immune response in intravesical BCG therapy for superficial bladder cancer",

abstract = "In intravesical therapy for superficial bladder carcinoma urothelial cells may, through the production of cytokines, contribute to the bacillus Calmette-Guerin (BCG)-induced local immunological reaction and associated antitumor efficacy. The aim of this study was to investigate such a role for the neutrophil-attracting cytokine interleukin-8 (IL-8). The appearance of IL-8 in patients urine after BCG therapy was compared with BCG-induced IL-6 and IL-2 and the stability of IL-8 in urine was tested. Compared to IL-6 and IL-2, a rapid induction of IL-8 was observed, occurring after the first BCG instillation. Urinary IL-8 was highly stable, even after 24 h incubation at 37 degrees C. The IL-8 concentration after the first instillation seemed to be associated with subsequent development of an immune response. Consequently, IL-8 seems an attractive candidate for investigation of its prognostic value for a clinical response to BCG therapy",

author = "\{de Boer\}, \{E. C.\} and L. Somogyi and \{de Ruiter\}, \{G. J.\} and \{de Reijke\}, \{T. M.\} and Kurth, \{K. H.\} and Schamhart, \{D. H.\}",

year = "1997",

doi = "10.1007/BF00941903",

language = "English",

volume = "25",

pages = "31--34",

journal = "Urological research",

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TY - JOUR

T1 - Role of interleukin-8 in onset of the immune response in intravesical BCG therapy for superficial bladder cancer

AU - de Boer, E. C.

AU - Somogyi, L.

AU - de Ruiter, G. J.

AU - de Reijke, T. M.

AU - Kurth, K. H.

AU - Schamhart, D. H.

PY - 1997

Y1 - 1997

N2 - In intravesical therapy for superficial bladder carcinoma urothelial cells may, through the production of cytokines, contribute to the bacillus Calmette-Guerin (BCG)-induced local immunological reaction and associated antitumor efficacy. The aim of this study was to investigate such a role for the neutrophil-attracting cytokine interleukin-8 (IL-8). The appearance of IL-8 in patients urine after BCG therapy was compared with BCG-induced IL-6 and IL-2 and the stability of IL-8 in urine was tested. Compared to IL-6 and IL-2, a rapid induction of IL-8 was observed, occurring after the first BCG instillation. Urinary IL-8 was highly stable, even after 24 h incubation at 37 degrees C. The IL-8 concentration after the first instillation seemed to be associated with subsequent development of an immune response. Consequently, IL-8 seems an attractive candidate for investigation of its prognostic value for a clinical response to BCG therapy

AB - In intravesical therapy for superficial bladder carcinoma urothelial cells may, through the production of cytokines, contribute to the bacillus Calmette-Guerin (BCG)-induced local immunological reaction and associated antitumor efficacy. The aim of this study was to investigate such a role for the neutrophil-attracting cytokine interleukin-8 (IL-8). The appearance of IL-8 in patients urine after BCG therapy was compared with BCG-induced IL-6 and IL-2 and the stability of IL-8 in urine was tested. Compared to IL-6 and IL-2, a rapid induction of IL-8 was observed, occurring after the first BCG instillation. Urinary IL-8 was highly stable, even after 24 h incubation at 37 degrees C. The IL-8 concentration after the first instillation seemed to be associated with subsequent development of an immune response. Consequently, IL-8 seems an attractive candidate for investigation of its prognostic value for a clinical response to BCG therapy

U2 - 10.1007/BF00941903

DO - 10.1007/BF00941903

M3 - Article

C2 - 9079743

SN - 0300-5623

VL - 25

SP - 31

EP - 34

JO - Urological research

JF - Urological research

IS - 1

ER -

Role of interleukin-8 in onset of the immune response in intravesical BCG therapy for superficial bladder cancer

Abstract

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