TY - JOUR
T1 - Risk Factors for Neurodevelopmental Impairment at 2- and 5-Years Corrected Age in Preterm Infants with Established Bronchopulmonary Dysplasia
AU - Katz, Trixie A
AU - van Kaam, Anton H
AU - Mugie, Suzanne M
AU - Aarnoudse-Moens, Cornelieke S H
AU - de Groof, Femke
AU - van Kempen, Anne A M W
AU - van den Heuvel, Maria E N
AU - Vogelzang, Judith
AU - Rijpert, Maarten
AU - Schiering, Irene A
AU - Koomen-Botman, Irene
AU - Visser, Fenna
AU - Leemhuis, Aleid G
AU - Onland, Wes
N1 - Publisher Copyright:
© 2023 The Author(s).
PY - 2023/10/18
Y1 - 2023/10/18
N2 - Introduction: The objective of this study was to identify risk factors for neurodevelopmental impairment (NDI) at 2- and 5-years corrected age (CA) in a cohort of preterm infants with established bronchopulmonary dysplasia (BPD). Methods: This single-center retrospective cohort study included infants born between2009and2016atagestationalage(GA)<30weekswith moderate or severe BPD at 36 weeks’ postmenstrual age. Perinatal characteristics, (social) demographics, and comorbidities werecollectedfromtheelectronicpatientrecords.Oddsratiosfor NDI were calculated with univariate and multivariate logistic regression analyses adjusting for potential confounders. Results: Of the 602 eligible infants, 123 infants were diagnosed with BPD. NDI was present in 30.3% and 56.1% at 2- and 5-years CA, respectively. The only independent risk factors associated with NDI in the multivariate analyses were birthweight (adjusted odds ratio [aOR] 0.74, 95% CI 0.57–0.95; aOR 0.70, 95% CI 0.54–0.91, respectively), small for GA (SGA) (aOR 3.25, 95% CI 1.09–9.61; aOR 5.44, 95% CI 1.62–18.2, respectively) at both time points, and male gender at 5-years CA (OR 2.49, 95% CI 1.11–5.57). Conclusion: Birthweight and SGA are independent risk factors for NDI at 2- and 5-years CA and male gender at 5-years CA in preterm infants with BPD. In contrast, well-known other risk factors for NDI in the general population of preterm infants, such as GA, maternal education, and neonatal comorbidities were not independently associated with NDI.
AB - Introduction: The objective of this study was to identify risk factors for neurodevelopmental impairment (NDI) at 2- and 5-years corrected age (CA) in a cohort of preterm infants with established bronchopulmonary dysplasia (BPD). Methods: This single-center retrospective cohort study included infants born between2009and2016atagestationalage(GA)<30weekswith moderate or severe BPD at 36 weeks’ postmenstrual age. Perinatal characteristics, (social) demographics, and comorbidities werecollectedfromtheelectronicpatientrecords.Oddsratiosfor NDI were calculated with univariate and multivariate logistic regression analyses adjusting for potential confounders. Results: Of the 602 eligible infants, 123 infants were diagnosed with BPD. NDI was present in 30.3% and 56.1% at 2- and 5-years CA, respectively. The only independent risk factors associated with NDI in the multivariate analyses were birthweight (adjusted odds ratio [aOR] 0.74, 95% CI 0.57–0.95; aOR 0.70, 95% CI 0.54–0.91, respectively), small for GA (SGA) (aOR 3.25, 95% CI 1.09–9.61; aOR 5.44, 95% CI 1.62–18.2, respectively) at both time points, and male gender at 5-years CA (OR 2.49, 95% CI 1.11–5.57). Conclusion: Birthweight and SGA are independent risk factors for NDI at 2- and 5-years CA and male gender at 5-years CA in preterm infants with BPD. In contrast, well-known other risk factors for NDI in the general population of preterm infants, such as GA, maternal education, and neonatal comorbidities were not independently associated with NDI.
KW - Bronchopulmonary dysplasia
KW - Neurodevelopmental impairment
KW - Risk factors
UR - https://www.scopus.com/pages/publications/85178159206
U2 - 10.1159/000533653
DO - 10.1159/000533653
M3 - Article
C2 - 37852207
SN - 1661-7800
SP - 1
EP - 8
JO - Neonatology
JF - Neonatology
ER -