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Review of potential anti-cancer properties of lactobacilli against breast cancer

  • Elnaz Ghorbani
  • , Asma Afshari
  • , Amir Avan
  • , Majid Khazaei*
  • , Saman Soleimanpour*
  • *Corresponding author for this work
  • Mashhad University of Medical Sciences

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Breast cancer is one of the leading cause of mortality among females worldwide. Regarding the side effects of current therapeutics, the development of novel target-specific treatments is a priority. Probiotic bacteria, as nutraceuticals, have shown anti-cancer potential, supported by cell culture-based and animal model studies. There are studies indicating differences in gut and breast microbiota between healthy individuals and cancerous patients. Given the immunomodulatory and regulatory effects of probiotics on hormone-mediated pathways, the consumption of probiotics can be considered a safe approach in breast cancer management. This review summarizes the recent research on the potential therapeutic roles of Lactobacillus strains in breast cancer.
Original languageEnglish
JournalFuture Oncology
Early online date2025
DOIs
Publication statusE-pub ahead of print - 2025
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Breast cancer
  • Lactobacillus
  • apoptosis
  • immune response
  • inflammation
  • microbiota
  • probiotics

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