TY - JOUR
T1 - Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients
AU - den Hartog, Yvette
AU - Malahe, S. Reshwan K.
AU - Rietdijk, Wim J. R.
AU - Dieterich, Marjolein
AU - Gommers, Lennert
AU - van Baarle, Debbie
AU - Diavatopoulos, Dimitri A.
AU - Messchendorp, A. Lianne
AU - van der Molen, Renate G.
AU - Remmerswaal, Ester B. M.
AU - Bemelman, Frederike J.
AU - Kho, Marcia M. L.
AU - GeurtsvanKessel, Corine H.
AU - Koopmans, Marion P. G.
AU - Gansevoort, Ron T.
AU - Hilbrands, Luuk B.
AU - Sanders, Jan-Stephan
AU - Reinders, Marlies E. J.
AU - Baan, Carla C.
AU - de Vries, Rory D.
AU - van Binnendijk, Rob
AU - den Hartog, Gerco
AU - Rots, Nynke
AU - van Mourik, Djenolan
AU - Philipsen, Ria
AU - Mattheussens, Wouter B.
AU - Boer-Verschragen, Marieken J.
AU - Adema, Yvonne M. R.
AU - Vart, Priya
AU - Imhof, Celine
AU - van der Heiden, Marieke
AU - Standaar, Dorien
AU - Frölke, Sophie C.
AU - on behalf of RECOVAC Consortium
AU - ten Dam, Marc A. G. J.
AU - Hemmelder, Marc H.
AU - Bouwmans, Pim
AU - Baas, Marije C.
AU - Abrahams, Alferso C.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Kidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical in preventing severe disease, KTRs have attenuated vaccination-induced immune responses due to underlying kidney disease and immunosuppressive therapies. In this study, the effect of different COVID-19 booster strategies on SARS-CoV-2-specific T-cell responses was assessed in KTRs who showed a poor serological response after the first two mRNA-based primary vaccination doses. In these KTRs, a third vaccination dose led to an increase in antibody levels in the majority of patients. Production of IL-2 and IL-5 by SARS-CoV-2 specific T cells positively correlated with antibody levels, with stronger correlations compared to IFN-γ production, the ‘traditional’ cytokine to measure T-cell responses. Our study underscores the significance a balanced T-cell cytokine response to achieve robust antibody responses in KTRs. Furthermore, we show that multiple cytokines to assess T-cell responses should be explored to identify individuals in need of tailored vaccination strategies.
AB - Kidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical in preventing severe disease, KTRs have attenuated vaccination-induced immune responses due to underlying kidney disease and immunosuppressive therapies. In this study, the effect of different COVID-19 booster strategies on SARS-CoV-2-specific T-cell responses was assessed in KTRs who showed a poor serological response after the first two mRNA-based primary vaccination doses. In these KTRs, a third vaccination dose led to an increase in antibody levels in the majority of patients. Production of IL-2 and IL-5 by SARS-CoV-2 specific T cells positively correlated with antibody levels, with stronger correlations compared to IFN-γ production, the ‘traditional’ cytokine to measure T-cell responses. Our study underscores the significance a balanced T-cell cytokine response to achieve robust antibody responses in KTRs. Furthermore, we show that multiple cytokines to assess T-cell responses should be explored to identify individuals in need of tailored vaccination strategies.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105023989645&origin=inward
U2 - 10.1038/s44298-024-00015-7
DO - 10.1038/s44298-024-00015-7
M3 - Article
SN - 2948-1767
VL - 2
JO - NPJ Viruses
JF - NPJ Viruses
IS - 1
M1 - 7
ER -
SDG 3 Good Health and Well-being