Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling

Mees Botman; Josje M A Huisman; Alexandra Drakaki; Sanne L Maas; Agnieszka Witalisz-Siepracka; Dagmar Stoiber; Emiel P C van der Vorst; Ricky Siebeler; Marten A Hoeksema

Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling

Mees Botman
, Josje M A Huisman
, Alexandra Drakaki
, Sanne L Maas
, Agnieszka Witalisz-Siepracka
, Dagmar Stoiber
, Emiel P C van der Vorst
, Ricky Siebeler
, Marten A Hoeksema

Amsterdam Cardiovascular Sciences Institute
Department of Medical Biochemistry
RWTH Aachen University
Karl Landsteiner University of Health Sciences

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Botman et al. reveal that IFN-γ can rapidly activate STAT3 in macrophages, forming STAT1-STAT3 heterodimers that fine-tune gene expression. This discovery uncovers a new layer of complexity in cytokine signaling and macrophage activation, broadening our understanding of immune regulation.

Original language	English
Article number	116985
Pages (from-to)	116985
Journal	Cell reports
Volume	45
Issue number	2
Publication status	Published - 24 Feb 2026

Keywords

CP: immunology
IFN-γ
JAK
STAT
cytokine
interferon
macrophages
transcription

Cite this

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title = "Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling",

abstract = "Botman et al. reveal that IFN-γ can rapidly activate STAT3 in macrophages, forming STAT1-STAT3 heterodimers that fine-tune gene expression. This discovery uncovers a new layer of complexity in cytokine signaling and macrophage activation, broadening our understanding of immune regulation.",

keywords = "CP: immunology, IFN-γ, JAK, STAT, cytokine, interferon, macrophages, transcription",

author = "Mees Botman and Huisman, \{Josje M A\} and Alexandra Drakaki and Maas, \{Sanne L\} and Agnieszka Witalisz-Siepracka and Dagmar Stoiber and \{van der Vorst\}, \{Emiel P C\} and Ricky Siebeler and Hoeksema, \{Marten A\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/",

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AU - Huisman, Josje M A

AU - Drakaki, Alexandra

AU - Maas, Sanne L

AU - Witalisz-Siepracka, Agnieszka

AU - Stoiber, Dagmar

AU - van der Vorst, Emiel P C

AU - Siebeler, Ricky

AU - Hoeksema, Marten A

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AB - Botman et al. reveal that IFN-γ can rapidly activate STAT3 in macrophages, forming STAT1-STAT3 heterodimers that fine-tune gene expression. This discovery uncovers a new layer of complexity in cytokine signaling and macrophage activation, broadening our understanding of immune regulation.

KW - CP: immunology

KW - IFN-γ

KW - JAK

KW - STAT

KW - cytokine

KW - interferon

KW - macrophages

KW - transcription

UR - https://www.scopus.com/pages/publications/105031635582

M3 - Article

C2 - 41671082

SN - 2211-1247

VL - 45

SP - 116985

JO - Cell reports

JF - Cell reports

IS - 2

M1 - 116985

ER -

Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling

Abstract

Keywords

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