Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment

Maja A. A. Binnewijzend; Menno M. Schoonheim; Ernesto Sanz-Arigita; Alle Meije Wink; Wiesje M. van der Flier; Nelleke Tolboom; Sofie M. Adriaanse; Jessica S. Damoiseaux; Philip Scheltens; Bart N. M. van Berckel; Frederik Barkhof

doi:10.1016/j.neurobiolaging.2011.07.003

Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment

Maja A. A. Binnewijzend
, Menno M. Schoonheim
, Ernesto Sanz-Arigita
, Alle Meije Wink
, Wiesje M. van der Flier
, Nelleke Tolboom
, Sofie M. Adriaanse
, Jessica S. Damoiseaux
, Philip Scheltens
, Bart N. M. van Berckel
, Frederik Barkhof

pre-AMC

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Regional functional connectivity (FC) of 39 patients with Alzheimer's disease (AD), 23 patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied using resting-state functional magnetic resonance imaging (rs-fMRI). After a mean follow-up of 2.8 +/- 1.9 years, 7 MCI patients converted to AD, while 14 patients remained cognitively stable. Resting-state functional magnetic resonance imaging scans were analyzed using independent component analysis (ICA), followed by a "dual-regression" technique to create and compare subject-specific maps of each independent spatiotemporal component, correcting for age, sex, and gray matter atrophy. AD patients displayed lower FC within the default-mode network (DMN) in the precuneus and posterior cingulate cortex compared with controls, independent of cortical atrophy. Regional FC values of MCI patients were numerically in between AD patients and controls, but only the difference between AD and stable MCI patients was statistically significant. Correlation with cognitive dysfunction demonstrated the clinical relevance of FC changes within the DMN. In conclusion, clinically relevant decreased FC within the DMN was observed in AD. (C) 2012 Elsevier Inc. All rights reserved

Original language	English
Pages (from-to)	2018-2028
Journal	Neurobiology of aging
Volume	33
Issue number	9
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.07.003
Publication status	Published - 2012

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Binnewijzend, M. A. A., Schoonheim, M. M., Sanz-Arigita, E., Wink, A. M., van der Flier, W. M., Tolboom, N., Adriaanse, S. M., Damoiseaux, J. S., Scheltens, P., van Berckel, B. N. M., & Barkhof, F. (2012). Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment. Neurobiology of aging, 33(9), 2018-2028. https://doi.org/10.1016/j.neurobiolaging.2011.07.003

@article{2a4cfc21bee8424cba07a3d697f6d9c0,

title = "Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment",

abstract = "Regional functional connectivity (FC) of 39 patients with Alzheimer's disease (AD), 23 patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied using resting-state functional magnetic resonance imaging (rs-fMRI). After a mean follow-up of 2.8 +/- 1.9 years, 7 MCI patients converted to AD, while 14 patients remained cognitively stable. Resting-state functional magnetic resonance imaging scans were analyzed using independent component analysis (ICA), followed by a {"}dual-regression{"} technique to create and compare subject-specific maps of each independent spatiotemporal component, correcting for age, sex, and gray matter atrophy. AD patients displayed lower FC within the default-mode network (DMN) in the precuneus and posterior cingulate cortex compared with controls, independent of cortical atrophy. Regional FC values of MCI patients were numerically in between AD patients and controls, but only the difference between AD and stable MCI patients was statistically significant. Correlation with cognitive dysfunction demonstrated the clinical relevance of FC changes within the DMN. In conclusion, clinically relevant decreased FC within the DMN was observed in AD. (C) 2012 Elsevier Inc. All rights reserved",

author = "Binnewijzend, \{Maja A. A.\} and Schoonheim, \{Menno M.\} and Ernesto Sanz-Arigita and Wink, \{Alle Meije\} and \{van der Flier\}, \{Wiesje M.\} and Nelleke Tolboom and Adriaanse, \{Sofie M.\} and Damoiseaux, \{Jessica S.\} and Philip Scheltens and \{van Berckel\}, \{Bart N. M.\} and Frederik Barkhof",

year = "2012",

doi = "10.1016/j.neurobiolaging.2011.07.003",

language = "English",

volume = "33",

pages = "2018--2028",

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TY - JOUR

T1 - Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment

AU - Binnewijzend, Maja A. A.

AU - Schoonheim, Menno M.

AU - Sanz-Arigita, Ernesto

AU - Wink, Alle Meije

AU - van der Flier, Wiesje M.

AU - Tolboom, Nelleke

AU - Adriaanse, Sofie M.

AU - Damoiseaux, Jessica S.

AU - Scheltens, Philip

AU - van Berckel, Bart N. M.

AU - Barkhof, Frederik

PY - 2012

Y1 - 2012

N2 - Regional functional connectivity (FC) of 39 patients with Alzheimer's disease (AD), 23 patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied using resting-state functional magnetic resonance imaging (rs-fMRI). After a mean follow-up of 2.8 +/- 1.9 years, 7 MCI patients converted to AD, while 14 patients remained cognitively stable. Resting-state functional magnetic resonance imaging scans were analyzed using independent component analysis (ICA), followed by a "dual-regression" technique to create and compare subject-specific maps of each independent spatiotemporal component, correcting for age, sex, and gray matter atrophy. AD patients displayed lower FC within the default-mode network (DMN) in the precuneus and posterior cingulate cortex compared with controls, independent of cortical atrophy. Regional FC values of MCI patients were numerically in between AD patients and controls, but only the difference between AD and stable MCI patients was statistically significant. Correlation with cognitive dysfunction demonstrated the clinical relevance of FC changes within the DMN. In conclusion, clinically relevant decreased FC within the DMN was observed in AD. (C) 2012 Elsevier Inc. All rights reserved

AB - Regional functional connectivity (FC) of 39 patients with Alzheimer's disease (AD), 23 patients with mild cognitive impairment (MCI), and 43 healthy elderly controls was studied using resting-state functional magnetic resonance imaging (rs-fMRI). After a mean follow-up of 2.8 +/- 1.9 years, 7 MCI patients converted to AD, while 14 patients remained cognitively stable. Resting-state functional magnetic resonance imaging scans were analyzed using independent component analysis (ICA), followed by a "dual-regression" technique to create and compare subject-specific maps of each independent spatiotemporal component, correcting for age, sex, and gray matter atrophy. AD patients displayed lower FC within the default-mode network (DMN) in the precuneus and posterior cingulate cortex compared with controls, independent of cortical atrophy. Regional FC values of MCI patients were numerically in between AD patients and controls, but only the difference between AD and stable MCI patients was statistically significant. Correlation with cognitive dysfunction demonstrated the clinical relevance of FC changes within the DMN. In conclusion, clinically relevant decreased FC within the DMN was observed in AD. (C) 2012 Elsevier Inc. All rights reserved

U2 - 10.1016/j.neurobiolaging.2011.07.003

DO - 10.1016/j.neurobiolaging.2011.07.003

M3 - Article

C2 - 21862179

SN - 0197-4580

VL - 33

SP - 2018

EP - 2028

JO - Neurobiology of aging

JF - Neurobiology of aging

IS - 9

ER -

Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment

Abstract

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