Reproducibility of exhaled nitric oxide measurements in overweight and obese adults

Willemien Thijs; Renée de Mutsert; Saskia le Cessie; Pieter S. Hiemstra; Frits R. Rosendaal; Saskia Middeldorp; Klaus F. Rabe

doi:10.1186/1756-0500-7-775

Reproducibility of exhaled nitric oxide measurements in overweight and obese adults

Willemien Thijs
, Renée de Mutsert
, Saskia le Cessie
, Pieter S. Hiemstra
, Frits R. Rosendaal
, Saskia Middeldorp
, Klaus F. Rabe

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Exhaled nitric oxide is a noninvasive measure of airway inflammation that can be detected by a handheld device. Obesity may influence the reproducibility of exhaled nitric oxide measurements, by - for instance - decreased expiratory reserve volume. We analyzed triple exhaled nitric oxide measurements from 553 participants (aged 45 to 65 years with a body mass index ≥27 kg/m2) of the Netherlands Epidemiology of Obesity Study. The interclass correlation coefficient (single measurement reliability) was 0.965 (95% CI: 0.960, 0.970). We conclude that for assessment of exhaled nitric oxide in large cohorts of overweight and obese adults a single measurement suffices

Original language	English
Pages (from-to)	775
Journal	BMC research notes
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/1756-0500-7-775
Publication status	Published - 2014

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10.1186/1756-0500-7-775

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title = "Reproducibility of exhaled nitric oxide measurements in overweight and obese adults",

abstract = "Exhaled nitric oxide is a noninvasive measure of airway inflammation that can be detected by a handheld device. Obesity may influence the reproducibility of exhaled nitric oxide measurements, by - for instance - decreased expiratory reserve volume. We analyzed triple exhaled nitric oxide measurements from 553 participants (aged 45 to 65 years with a body mass index ≥27 kg/m2) of the Netherlands Epidemiology of Obesity Study. The interclass correlation coefficient (single measurement reliability) was 0.965 (95\% CI: 0.960, 0.970). We conclude that for assessment of exhaled nitric oxide in large cohorts of overweight and obese adults a single measurement suffices",

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AU - Thijs, Willemien

AU - de Mutsert, Renée

AU - le Cessie, Saskia

AU - Hiemstra, Pieter S.

AU - Rosendaal, Frits R.

AU - Middeldorp, Saskia

AU - Rabe, Klaus F.

PY - 2014

Y1 - 2014

N2 - Exhaled nitric oxide is a noninvasive measure of airway inflammation that can be detected by a handheld device. Obesity may influence the reproducibility of exhaled nitric oxide measurements, by - for instance - decreased expiratory reserve volume. We analyzed triple exhaled nitric oxide measurements from 553 participants (aged 45 to 65 years with a body mass index ≥27 kg/m2) of the Netherlands Epidemiology of Obesity Study. The interclass correlation coefficient (single measurement reliability) was 0.965 (95% CI: 0.960, 0.970). We conclude that for assessment of exhaled nitric oxide in large cohorts of overweight and obese adults a single measurement suffices

AB - Exhaled nitric oxide is a noninvasive measure of airway inflammation that can be detected by a handheld device. Obesity may influence the reproducibility of exhaled nitric oxide measurements, by - for instance - decreased expiratory reserve volume. We analyzed triple exhaled nitric oxide measurements from 553 participants (aged 45 to 65 years with a body mass index ≥27 kg/m2) of the Netherlands Epidemiology of Obesity Study. The interclass correlation coefficient (single measurement reliability) was 0.965 (95% CI: 0.960, 0.970). We conclude that for assessment of exhaled nitric oxide in large cohorts of overweight and obese adults a single measurement suffices

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DO - 10.1186/1756-0500-7-775

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VL - 7

SP - 775

JO - BMC research notes

JF - BMC research notes

IS - 1

ER -

Reproducibility of exhaled nitric oxide measurements in overweight and obese adults

Abstract

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