Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+

Stan F. J. van de Graaf; Inge Boullart; Joost G. J. Hoenderop; René J. M. Bindels

doi:10.1016/j.jsbmb.2004.03.029

Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+

Stan F. J. van de Graaf
, Inge Boullart
, Joost G. J. Hoenderop
, René J. M. Bindels

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Active, transepithelial Ca(2+) transport is a pivotal process in the regulation of Ca(2+) homeostasis and consists of three sequential steps: apical Ca(2+) influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca(2+) transport and these highly selective Ca(2+) channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1alpha,25-dihydroxyVitamin D(3) (1alpha,25(OH)(2)D(3)), dietary Ca(2+) and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca(2+) transport will be discussed

Original language	English
Pages (from-to)	303-308
Journal	Journal of steroid biochemistry and molecular biology
Volume	89-90
Issue number	1-5
DOIs	https://doi.org/10.1016/j.jsbmb.2004.03.029
Publication status	Published - 2004

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10.1016/j.jsbmb.2004.03.029

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title = "Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+",

abstract = "Active, transepithelial Ca(2+) transport is a pivotal process in the regulation of Ca(2+) homeostasis and consists of three sequential steps: apical Ca(2+) influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca(2+) transport and these highly selective Ca(2+) channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1alpha,25-dihydroxyVitamin D(3) (1alpha,25(OH)(2)D(3)), dietary Ca(2+) and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca(2+) transport will be discussed",

author = "\{van de Graaf\}, \{Stan F. J.\} and Inge Boullart and Hoenderop, \{Joost G. J.\} and Bindels, \{Ren{\'e} J. M.\}",

year = "2004",

doi = "10.1016/j.jsbmb.2004.03.029",

language = "English",

volume = "89-90",

pages = "303--308",

journal = "Journal of steroid biochemistry and molecular biology",

issn = "0960-0760",

publisher = "Elsevier Limited",

number = "1-5",

}

TY - JOUR

T1 - Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+

AU - van de Graaf, Stan F. J.

AU - Boullart, Inge

AU - Hoenderop, Joost G. J.

AU - Bindels, René J. M.

PY - 2004

Y1 - 2004

N2 - Active, transepithelial Ca(2+) transport is a pivotal process in the regulation of Ca(2+) homeostasis and consists of three sequential steps: apical Ca(2+) influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca(2+) transport and these highly selective Ca(2+) channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1alpha,25-dihydroxyVitamin D(3) (1alpha,25(OH)(2)D(3)), dietary Ca(2+) and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca(2+) transport will be discussed

AB - Active, transepithelial Ca(2+) transport is a pivotal process in the regulation of Ca(2+) homeostasis and consists of three sequential steps: apical Ca(2+) influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca(2+) transport and these highly selective Ca(2+) channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1alpha,25-dihydroxyVitamin D(3) (1alpha,25(OH)(2)D(3)), dietary Ca(2+) and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca(2+) transport will be discussed

U2 - 10.1016/j.jsbmb.2004.03.029

DO - 10.1016/j.jsbmb.2004.03.029

M3 - Article

C2 - 15225790

SN - 0960-0760

VL - 89-90

SP - 303

EP - 308

JO - Journal of steroid biochemistry and molecular biology

JF - Journal of steroid biochemistry and molecular biology

IS - 1-5

ER -

Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+

Abstract

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