TY - JOUR
T1 - Region-specific drivers of CSF mobility measured with MRI in humans
AU - Hirschler, Lydiane
AU - Runderkamp, Bobby A.
AU - Decker, Andreas
AU - van Harten, Thijs W.
AU - Scheyhing, Paul
AU - Ehses, Philipp
AU - Petitclerc, Léonie
AU - Layer, Julia
AU - Pracht, Eberhard
AU - Coolen, Bram F.
AU - van der Zwaag, Wietske
AU - Stöcker, Tony
AU - Vollmuth, Philipp
AU - Paech, Daniel
AU - Effland, Alexander
AU - van Walderveen, Marianne A.A.
AU - Radbruch, Alexander
AU - van Buchem, Mark A.
AU - Petzold, Gabor C.
AU - van Veluw, Susanne J.
AU - Caan, Matthan W.A.
AU - Deike, Katerina
AU - van Osch, Matthias J.P.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/11
Y1 - 2025/11
N2 - Many neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries highlighted perivascular spaces, which are cerebrospinal fluid (CSF)-filled spaces, as the channels of brain clearance. The forces driving CSF mobility within perivascular spaces are still debated. Here we present a noninvasive, CSF-specific magnetic resonance imaging technique (CSF-Selective T2-prepared REadout with Acceleration and Mobility-encoding) that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels, which is close to protein production sites. We find region-specific drivers of CSF mobility and demonstrate that CSF mobility can be increased by entraining vasomotion. Furthermore, we find region-specific CSF mobility alterations in patients with cerebral amyloid angiopathy, a brain disorder associated with clearance impairment. The availability of this technique opens up avenues to investigate the impact of CSF-mediated clearance in neurodegeneration and sleep.
AB - Many neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries highlighted perivascular spaces, which are cerebrospinal fluid (CSF)-filled spaces, as the channels of brain clearance. The forces driving CSF mobility within perivascular spaces are still debated. Here we present a noninvasive, CSF-specific magnetic resonance imaging technique (CSF-Selective T2-prepared REadout with Acceleration and Mobility-encoding) that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels, which is close to protein production sites. We find region-specific drivers of CSF mobility and demonstrate that CSF mobility can be increased by entraining vasomotion. Furthermore, we find region-specific CSF mobility alterations in patients with cerebral amyloid angiopathy, a brain disorder associated with clearance impairment. The availability of this technique opens up avenues to investigate the impact of CSF-mediated clearance in neurodegeneration and sleep.
UR - https://www.scopus.com/pages/publications/105019107955
U2 - 10.1038/s41593-025-02073-3
DO - 10.1038/s41593-025-02073-3
M3 - Article
C2 - 41087750
AN - SCOPUS:105019107955
SN - 1097-6256
VL - 28
SP - 2392
EP - 2401
JO - Nature neuroscience
JF - Nature neuroscience
IS - 11
ER -