Redefining the role of biomarkers in heart failure trials: expert consensus document

Frank Kramer; Hani N. Sabbah; James J. Januzzi; Faiez Zannad; J. Peter van Tintelen; Erik B. Schelbert; Raymond J. Kim; Hendrik Milting; Richardus Vonk; Brien Neudeck; Richard Clark; Klaus Witte; Wilfried Dinh; Burkert Pieske; Javed Butler; Mihai Gheorghiade

doi:10.1007/s10741-017-9608-5

Redefining the role of biomarkers in heart failure trials: expert consensus document

Frank Kramer
, Hani N. Sabbah
, James J. Januzzi
, Faiez Zannad
, J. Peter van Tintelen
, Erik B. Schelbert
, Raymond J. Kim
, Hendrik Milting
, Richardus Vonk
, Brien Neudeck
, Richard Clark
, Klaus Witte
, Wilfried Dinh
, Burkert Pieske
, Javed Butler
, Mihai Gheorghiade

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatments for heart failure. Biomarkers play an important role in patient selection and monitoring in drug trials and in clinical management. The present review gives an overview of the role of available molecular, imaging, and device-derived digital biomarkers in heart failure drug development and highlights capabilities and limitations of biomarker use in this context

Original language	English
Pages (from-to)	263-277
Journal	Heart failure reviews
Volume	22
Issue number	3
Early online date	2017
DOIs	https://doi.org/10.1007/s10741-017-9608-5
Publication status	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/s10741-017-9608-5

Redefining-the-role-of-biomarkers-in-heart-failure-trials-expert-consensus-document.pdfFinal published version, 731 KBLicence: Taverne

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Kramer, F., Sabbah, H. N., Januzzi, J. J., Zannad, F., van Tintelen, J. P., Schelbert, E. B., Kim, R. J., Milting, H., Vonk, R., Neudeck, B., Clark, R., Witte, K., Dinh, W., Pieske, B., Butler, J., & Gheorghiade, M. (2017). Redefining the role of biomarkers in heart failure trials: expert consensus document. Heart failure reviews, 22(3), 263-277. https://doi.org/10.1007/s10741-017-9608-5

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title = "Redefining the role of biomarkers in heart failure trials: expert consensus document",

abstract = "Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatments for heart failure. Biomarkers play an important role in patient selection and monitoring in drug trials and in clinical management. The present review gives an overview of the role of available molecular, imaging, and device-derived digital biomarkers in heart failure drug development and highlights capabilities and limitations of biomarker use in this context",

author = "Frank Kramer and Sabbah, \{Hani N.\} and Januzzi, \{James J.\} and Faiez Zannad and \{van Tintelen\}, \{J. Peter\} and Schelbert, \{Erik B.\} and Kim, \{Raymond J.\} and Hendrik Milting and Richardus Vonk and Brien Neudeck and Richard Clark and Klaus Witte and Wilfried Dinh and Burkert Pieske and Javed Butler and Mihai Gheorghiade",

year = "2017",

doi = "10.1007/s10741-017-9608-5",

language = "English",

volume = "22",

pages = "263--277",

journal = "Heart failure reviews",

issn = "1382-4147",

publisher = "Springer Netherlands",

number = "3",

}

Kramer, F, Sabbah, HN, Januzzi, JJ, Zannad, F, van Tintelen, JP, Schelbert, EB, Kim, RJ, Milting, H, Vonk, R, Neudeck, B, Clark, R, Witte, K, Dinh, W, Pieske, B, Butler, J & Gheorghiade, M 2017, 'Redefining the role of biomarkers in heart failure trials: expert consensus document', Heart failure reviews, vol. 22, no. 3, pp. 263-277. https://doi.org/10.1007/s10741-017-9608-5

TY - JOUR

T1 - Redefining the role of biomarkers in heart failure trials: expert consensus document

AU - Kramer, Frank

AU - Sabbah, Hani N.

AU - Januzzi, James J.

AU - Zannad, Faiez

AU - van Tintelen, J. Peter

AU - Schelbert, Erik B.

AU - Kim, Raymond J.

AU - Milting, Hendrik

AU - Vonk, Richardus

AU - Neudeck, Brien

AU - Clark, Richard

AU - Witte, Klaus

AU - Dinh, Wilfried

AU - Pieske, Burkert

AU - Butler, Javed

AU - Gheorghiade, Mihai

PY - 2017

Y1 - 2017

N2 - Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatments for heart failure. Biomarkers play an important role in patient selection and monitoring in drug trials and in clinical management. The present review gives an overview of the role of available molecular, imaging, and device-derived digital biomarkers in heart failure drug development and highlights capabilities and limitations of biomarker use in this context

AB - Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatments for heart failure. Biomarkers play an important role in patient selection and monitoring in drug trials and in clinical management. The present review gives an overview of the role of available molecular, imaging, and device-derived digital biomarkers in heart failure drug development and highlights capabilities and limitations of biomarker use in this context

U2 - 10.1007/s10741-017-9608-5

DO - 10.1007/s10741-017-9608-5

M3 - Review article

C2 - 28332132

SN - 1382-4147

VL - 22

SP - 263

EP - 277

JO - Heart failure reviews

JF - Heart failure reviews

IS - 3

ER -

Redefining the role of biomarkers in heart failure trials: expert consensus document

Abstract

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