TY - JOUR
T1 - Recent developments in frailty identification, management, risk factors and prevention
T2 - A narrative review of leading journals in geriatrics and gerontology
AU - Dent, Elsa
AU - Hanlon, Peter
AU - Sim, Marc
AU - Jylhävä, Juulia
AU - Liu, Zuyun
AU - Vetrano, Davide L.
AU - Stolz, Erwin
AU - Pérez-Zepeda, Mario Ulises
AU - Crabtree, Daniel
AU - Nicholson, Caroline
AU - Job, Jenny
AU - Ambagtsheer, Rachel C.
AU - Ward, Paul R.
AU - Shi, Sandra M.
AU - Huynh, Quan
AU - Hoogendijk, Emiel O.
N1 - Funding Information:
The Frailty Epidemiology Research Network (EPI-FRAIL) is an international collaborative project aimed at filling knowledge gaps in the field of frailty epidemiology. The network was established as part of a NWO/ZonMw Veni fellowship awarded to E.O. Hoogendijk (Grant no. 91618067 ). P. Hanlon is funded through a Clinical Research Training Fellowship from the Medical Research Council (Grant reference: MR/S021949/1 ). Z. Liu was supported by the Soft Science Research Program of Zhejiang Province ( 2023KXCX-KT011 ). J. Jylhävä has received grant support from the Swedish Research Council (grant no. 2018-02077 ), the Academy of Finland (grant no. 349335 ), the Sigrid Jusélius Foundation , the Yrjö Jahnsson Foundation and the Instrumentarium Science Foundation . M. Sim is supported by a Royal Perth Hospital Research Foundation Career Advancement Fellowship and an Emerging Leader Fellowship from the Future Health Research and Innovation Fund (Department of Health, Western Australia). R. Ambagtsheer receives funding from the Australian Medical Research Future Fund (grant #MRF2016140 ). D. L. Vetrano receives financial support from the Swedish Research Council ( 2021-03324 ). S. Shi reports funding from the National Institute of Aging , R03AG078894-01 . None of the funding agencies had any role in the conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript.
Publisher Copyright:
© 2023 The Authors
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Frailty is an age-related clinical condition characterised by an increased susceptibility to stressors and an elevated risk of adverse outcomes such as mortality. In the light of global population ageing, the prevalence of frailty is expected to soar in coming decades. This narrative review provides critical insights into recent developments and emerging practices in frailty research regarding identification, management, risk factors, and prevention. We searched journals in the top two quartiles of geriatrics and gerontology (from Clarivate Journal Citation Reports) for articles published between 01 January 2018 and 20 December 2022. Several recent developments were identified, including new biomarkers and biomarker panels for frailty screening and diagnosis, using artificial intelligence to identify frailty, and investigating the altered response to medications by older adults with frailty. Other areas with novel developments included exercise (including technology-based exercise), multidimensional interventions, person-centred and integrated care, assistive technologies, analysis of frailty transitions, risk-factors, clinical guidelines, COVID-19, and potential future treatments. This review identified a strong need for the implementation and evaluation of cost-effective, community-based interventions to manage and prevent frailty. Our findings highlight the need to better identify and support older adults with frailty and involve those with frailty in shared decision-making regarding their care.
AB - Frailty is an age-related clinical condition characterised by an increased susceptibility to stressors and an elevated risk of adverse outcomes such as mortality. In the light of global population ageing, the prevalence of frailty is expected to soar in coming decades. This narrative review provides critical insights into recent developments and emerging practices in frailty research regarding identification, management, risk factors, and prevention. We searched journals in the top two quartiles of geriatrics and gerontology (from Clarivate Journal Citation Reports) for articles published between 01 January 2018 and 20 December 2022. Several recent developments were identified, including new biomarkers and biomarker panels for frailty screening and diagnosis, using artificial intelligence to identify frailty, and investigating the altered response to medications by older adults with frailty. Other areas with novel developments included exercise (including technology-based exercise), multidimensional interventions, person-centred and integrated care, assistive technologies, analysis of frailty transitions, risk-factors, clinical guidelines, COVID-19, and potential future treatments. This review identified a strong need for the implementation and evaluation of cost-effective, community-based interventions to manage and prevent frailty. Our findings highlight the need to better identify and support older adults with frailty and involve those with frailty in shared decision-making regarding their care.
KW - Humans
KW - Aged
KW - Frailty/diagnosis
KW - Artificial Intelligence
KW - Periodicals as Topic
KW - Geriatrics
KW - Risk Management
KW - Frail Elderly
KW - Geriatric Assessment
UR - https://www.scopus.com/pages/publications/85173240185
U2 - 10.1016/j.arr.2023.102082
DO - 10.1016/j.arr.2023.102082
M3 - Review article
C2 - 37797723
SN - 1568-1637
VL - 91
SP - 102082
JO - Ageing research reviews
JF - Ageing research reviews
M1 - 102082
ER -