Ras caught in another affair: The exchange factors for Ral

Rob Mf Wolthuis; Johannes L. Bos

doi:10.1016/S0959-437X(99)80016-1

Ras caught in another affair: The exchange factors for Ral

Rob Mf Wolthuis
, Johannes L. Bos^*

^*Corresponding author for this work

U.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.

Original language	English
Pages (from-to)	112-117
Number of pages	6
Journal	Current opinion in genetics & development
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S0959-437X(99)80016-1
Publication status	Published - 1 Feb 1999
Externally published	Yes

Access to Document

10.1016/S0959-437X(99)80016-1

Cite this

@article{70d9d6ca63df4b0390a36d2fe4898937,

title = "Ras caught in another affair: The exchange factors for Ral",

abstract = "The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.",

author = "Wolthuis, \{Rob Mf\} and Bos, \{Johannes L.\}",

note = "Funding Information: The authors thank Boudewijn Burgering, Kris Reedquist and Fried Zwartkruis for critical reading the manuscript and all our colleagues for stimulating discussions. We thank the Netherlands organisation for Scientific Research (NWO) and the Dutch Cancer Society (KWF) for the support of our work on Ras signaling.",

year = "1999",

month = feb,

day = "1",

doi = "10.1016/S0959-437X(99)80016-1",

language = "English",

volume = "9",

pages = "112--117",

journal = "Current opinion in genetics \& development",

issn = "0959-437X",

publisher = "Elsevier Limited",

number = "1",

}

TY - JOUR

T1 - Ras caught in another affair

T2 - The exchange factors for Ral

AU - Wolthuis, Rob Mf

AU - Bos, Johannes L.

N1 - Funding Information: The authors thank Boudewijn Burgering, Kris Reedquist and Fried Zwartkruis for critical reading the manuscript and all our colleagues for stimulating discussions. We thank the Netherlands organisation for Scientific Research (NWO) and the Dutch Cancer Society (KWF) for the support of our work on Ras signaling.

PY - 1999/2/1

Y1 - 1999/2/1

N2 - The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.

AB - The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.

UR - https://www.scopus.com/pages/publications/0033029811

U2 - 10.1016/S0959-437X(99)80016-1

DO - 10.1016/S0959-437X(99)80016-1

M3 - Article

C2 - 10072355

SN - 0959-437X

VL - 9

SP - 112

EP - 117

JO - Current opinion in genetics & development

JF - Current opinion in genetics & development

IS - 1

ER -

Ras caught in another affair: The exchange factors for Ral

Abstract

Access to Document

Other files and links

Fingerprint

Cite this