TY - JOUR
T1 - Radiotherapie bij borstsparende behandeling
T2 - verleden, heden en toekomst
AU - Scholten, Astrid N.
AU - Rutgers, Emiel J. Th
AU - Bartelink, Harry G. M. M.
PY - 2015
Y1 - 2015
N2 - Clinical trials in the 1970s and 80s showed the survival rate of women with early breast cancer (stage I-II, 0-5 cm) who underwent treatment by means of breast conserving therapy (BCT) to be equal to that of those who underwent radical mastectomy. Since the 1980s the risk of both local recurrence and late toxicity after BCT has been significantly reduced. Studies are identifying subgroups of patients with low-risk breast cancer in whom it is possible to abstain from giving further radiation treatment. Over recent years the number of effective systemic therapy options has increased, leading to a reduction in the risk of recurrence in breast cancer. Developments in genetic profiling are expected to lead to further individualized loco-regional treatment.
AB - Clinical trials in the 1970s and 80s showed the survival rate of women with early breast cancer (stage I-II, 0-5 cm) who underwent treatment by means of breast conserving therapy (BCT) to be equal to that of those who underwent radical mastectomy. Since the 1980s the risk of both local recurrence and late toxicity after BCT has been significantly reduced. Studies are identifying subgroups of patients with low-risk breast cancer in whom it is possible to abstain from giving further radiation treatment. Over recent years the number of effective systemic therapy options has increased, leading to a reduction in the risk of recurrence in breast cancer. Developments in genetic profiling are expected to lead to further individualized loco-regional treatment.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991369089&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/26761640
M3 - Review article
C2 - 26761640
SN - 0028-2162
VL - 159
SP - A9289
JO - Nederlands tijdschrift voor geneeskunde
JF - Nederlands tijdschrift voor geneeskunde
ER -