Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium

Barbara C. van Munster; Marielle J. van Breemen; Perry D. Moerland; Dave Speijer; Sophia E. de Rooij; Christel J. Pfrommer; Marcel Levi; Markus W. Hollmann; Johannes M. Aerts; Aeilko H. Zwinderman; Johanna C. Korevaar

doi:10.1176/jnp.2009.21.3.284

Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium

Barbara C. van Munster
, Marielle J. van Breemen
, Perry D. Moerland
, Dave Speijer
, Sophia E. de Rooij
, Christel J. Pfrommer
, Marcel Levi
, Markus W. Hollmann
, Johannes M. Aerts
, Aeilko H. Zwinderman
, Johanna C. Korevaar

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The aim of this study was to compare plasma and serum protein profiles in elderly acute hip fracture patients with and without delirium. The spectra from surface-enhanced laser desorption ionization (SELDI) using time-of-flight (TOF) mass spectrometry of 16 patients without and 16 patients with delirium (two groups of eight and eight) scored using the Confusion Assessment Method were compared. The most discriminating peak of 15.9 kDa in plasma in a testing group of eight patients with delirium to eight patients without delirium was confirmed in an independent validation group. Taking both groups together, three discriminating peaks of 7.97, 15.9, and 16.0 kDa were found in delirious patients. These peaks presumably correspond to hemoglobin-beta, its doubly charged ion, and its glycosylated form. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21: 284-291)

Original language	English
Pages (from-to)	284-291
Journal	Journal of neuropsychiatry and clinical neurosciences
Volume	21
Issue number	3
DOIs	https://doi.org/10.1176/jnp.2009.21.3.284
Publication status	Published - 2009

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van Munster, B. C., van Breemen, M. J., Moerland, P. D., Speijer, D., de Rooij, S. E., Pfrommer, C. J., Levi, M., Hollmann, M. W., Aerts, J. M., Zwinderman, A. H., & Korevaar, J. C. (2009). Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium. Journal of neuropsychiatry and clinical neurosciences, 21(3), 284-291. https://doi.org/10.1176/jnp.2009.21.3.284

@article{9ebfeb5701244e7c8f6857abd2f17b0d,

title = "Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium",

abstract = "The aim of this study was to compare plasma and serum protein profiles in elderly acute hip fracture patients with and without delirium. The spectra from surface-enhanced laser desorption ionization (SELDI) using time-of-flight (TOF) mass spectrometry of 16 patients without and 16 patients with delirium (two groups of eight and eight) scored using the Confusion Assessment Method were compared. The most discriminating peak of 15.9 kDa in plasma in a testing group of eight patients with delirium to eight patients without delirium was confirmed in an independent validation group. Taking both groups together, three discriminating peaks of 7.97, 15.9, and 16.0 kDa were found in delirious patients. These peaks presumably correspond to hemoglobin-beta, its doubly charged ion, and its glycosylated form. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21: 284-291)",

author = "\{van Munster\}, \{Barbara C.\} and \{van Breemen\}, \{Marielle J.\} and Moerland, \{Perry D.\} and Dave Speijer and \{de Rooij\}, \{Sophia E.\} and Pfrommer, \{Christel J.\} and Marcel Levi and Hollmann, \{Markus W.\} and Aerts, \{Johannes M.\} and Zwinderman, \{Aeilko H.\} and Korevaar, \{Johanna C.\}",

year = "2009",

doi = "10.1176/jnp.2009.21.3.284",

language = "English",

volume = "21",

pages = "284--291",

journal = "Journal of neuropsychiatry and clinical neurosciences",

issn = "0895-0172",

publisher = "American Psychiatric Association",

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TY - JOUR

T1 - Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium

AU - van Munster, Barbara C.

AU - van Breemen, Marielle J.

AU - Moerland, Perry D.

AU - Speijer, Dave

AU - de Rooij, Sophia E.

AU - Pfrommer, Christel J.

AU - Levi, Marcel

AU - Hollmann, Markus W.

AU - Aerts, Johannes M.

AU - Zwinderman, Aeilko H.

AU - Korevaar, Johanna C.

PY - 2009

Y1 - 2009

N2 - The aim of this study was to compare plasma and serum protein profiles in elderly acute hip fracture patients with and without delirium. The spectra from surface-enhanced laser desorption ionization (SELDI) using time-of-flight (TOF) mass spectrometry of 16 patients without and 16 patients with delirium (two groups of eight and eight) scored using the Confusion Assessment Method were compared. The most discriminating peak of 15.9 kDa in plasma in a testing group of eight patients with delirium to eight patients without delirium was confirmed in an independent validation group. Taking both groups together, three discriminating peaks of 7.97, 15.9, and 16.0 kDa were found in delirious patients. These peaks presumably correspond to hemoglobin-beta, its doubly charged ion, and its glycosylated form. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21: 284-291)

AB - The aim of this study was to compare plasma and serum protein profiles in elderly acute hip fracture patients with and without delirium. The spectra from surface-enhanced laser desorption ionization (SELDI) using time-of-flight (TOF) mass spectrometry of 16 patients without and 16 patients with delirium (two groups of eight and eight) scored using the Confusion Assessment Method were compared. The most discriminating peak of 15.9 kDa in plasma in a testing group of eight patients with delirium to eight patients without delirium was confirmed in an independent validation group. Taking both groups together, three discriminating peaks of 7.97, 15.9, and 16.0 kDa were found in delirious patients. These peaks presumably correspond to hemoglobin-beta, its doubly charged ion, and its glycosylated form. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21: 284-291)

U2 - 10.1176/jnp.2009.21.3.284

DO - 10.1176/jnp.2009.21.3.284

M3 - Article

C2 - 19776308

SN - 0895-0172

VL - 21

SP - 284

EP - 291

JO - Journal of neuropsychiatry and clinical neurosciences

JF - Journal of neuropsychiatry and clinical neurosciences

IS - 3

ER -

Proteomic Profiling of Plasma and Serum in Elderly Patients With Delirium

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