Protein translation and ER stress in intestinal homeostasis and cancer

C.N. Spaan

Protein translation and ER stress in intestinal homeostasis and cancer

C.N. Spaan

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

This thesis explores the interaction between protein translation control mechanisms and colon cancer.
We first investigate translation potential of cancer cells by implementing consecutive oncogenic mutations in intestinal organoids. We find increased global translation capacity following accumulation of mutations. We

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Universiteit van Amsterdam
Supervisors/Advisors	van de Graaf, Stan, Supervisor Heijmans, Jarom, Co-supervisor Dijkstra - Muncan, Vanesa, Co-supervisor
Award date	23 Jan 2026
Publication status	Published - 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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https://pure.uva.nl/ws/files/277090447/Thesis.pdf

Cite this

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title = "Protein translation and ER stress in intestinal homeostasis and cancer",

abstract = "This thesis explores the interaction between protein translation control mechanisms and colon cancer. We first investigate translation potential of cancer cells by implementing consecutive oncogenic mutations in intestinal organoids. We find increased global translation capacity following accumulation of mutations. We",

author = "C.N. Spaan",

year = "2026",

language = "English",

type = "Phd-Thesis - Research and graduation internal",

school = "Universiteit van Amsterdam",

}

TY - THES

T1 - Protein translation and ER stress in intestinal homeostasis and cancer

AU - Spaan, C.N.

PY - 2026

Y1 - 2026

N2 - This thesis explores the interaction between protein translation control mechanisms and colon cancer. We first investigate translation potential of cancer cells by implementing consecutive oncogenic mutations in intestinal organoids. We find increased global translation capacity following accumulation of mutations. We

AB - This thesis explores the interaction between protein translation control mechanisms and colon cancer. We first investigate translation potential of cancer cells by implementing consecutive oncogenic mutations in intestinal organoids. We find increased global translation capacity following accumulation of mutations. We

M3 - Phd-Thesis - Research and graduation internal

ER -

Protein translation and ER stress in intestinal homeostasis and cancer

Abstract

UN SDGs

Access to Document

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Cite this