Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia

Lukas H Haaksma; Raffaele Palmieri; Tom Reuvekamp; Jesse M Tettero; Lok Lam Ngai; Costa Bachas; Angèle Kelder; Willemijn J Scholten; Patrycja Gradowska; Valentina Arena; Anderson João Simione; Luca Maurillo; Adriano Venditti; Bob Löwenberg; Gert J Ossenkoppele; David C de Leeuw; Maura R V Ikoma-Colturato; Francesco Buccisano; Jacqueline Cloos

doi:10.1038/s41375-025-02825-x

Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia

Lukas H Haaksma
, Raffaele Palmieri
, Tom Reuvekamp
, Jesse M Tettero
, Lok Lam Ngai
, Costa Bachas
, Angèle Kelder
, Willemijn J Scholten
, Patrycja Gradowska
, Valentina Arena
, Anderson João Simione
, Luca Maurillo
, Adriano Venditti
, Bob Löwenberg
, Gert J Ossenkoppele
, David C de Leeuw
, Maura R V Ikoma-Colturato
, Francesco Buccisano
, Jacqueline Cloos

Department of Hematology
Amsterdam UMC Location Vrije Universiteit Amsterdam
The Netherlands
Hematology Department of Biomedicine and Prevention
University of Rome Tor Vergata
Cancer center Amsterdam
HOVON Foundation
Rotterdam
Erasmus MC Cancer Institute
GIMEMA Data Center
Flow Cytometry Laboratory
Hospital Amaral Carvalho - Jau
Hematology Clinic
Fondazione Policlinico Tor Vergata
‘Sapienza’ University of Rome, Rome, Italy

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Journal	Leukemia
Early online date	10 Dec 2025
DOIs	https://doi.org/10.1038/s41375-025-02825-x
Publication status	E-pub ahead of print - 10 Dec 2025

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SDG 3 Good Health and Well-being

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Haaksma, L. H., Palmieri, R., Reuvekamp, T., Tettero, J. M., Ngai, L. L., Bachas, C., Kelder, A., Scholten, W. J., Gradowska, P., Arena, V., João Simione, A., Maurillo, L., Venditti, A., Löwenberg, B., Ossenkoppele, G. J., de Leeuw, D. C., Ikoma-Colturato, M. R. V., Buccisano, F., & Cloos, J. (2025). Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia. Leukemia. Advance online publication. https://doi.org/10.1038/s41375-025-02825-x

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title = "Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia",

author = "Haaksma, \{Lukas H\} and Raffaele Palmieri and Tom Reuvekamp and Tettero, \{Jesse M\} and Ngai, \{Lok Lam\} and Costa Bachas and Ang{\`e}le Kelder and Scholten, \{Willemijn J\} and Patrycja Gradowska and Valentina Arena and \{Jo{\~a}o Simione\}, Anderson and Luca Maurillo and Adriano Venditti and Bob L{\"o}wenberg and Ossenkoppele, \{Gert J\} and \{de Leeuw\}, \{David C\} and Ikoma-Colturato, \{Maura R V\} and Francesco Buccisano and Jacqueline Cloos",

year = "2025",

month = dec,

day = "10",

doi = "10.1038/s41375-025-02825-x",

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Haaksma, LH, Palmieri, R, Reuvekamp, T , Tettero, JM , Ngai, LL , Bachas, C, Kelder, A, Scholten, WJ, Gradowska, P, Arena, V, João Simione, A, Maurillo, L, Venditti, A, Löwenberg, B, Ossenkoppele, GJ, de Leeuw, DC, Ikoma-Colturato, MRV, Buccisano, F & Cloos, J 2025, 'Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia', Leukemia. https://doi.org/10.1038/s41375-025-02825-x

TY - JOUR

T1 - Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia

AU - Haaksma, Lukas H

AU - Palmieri, Raffaele

AU - Reuvekamp, Tom

AU - Tettero, Jesse M

AU - Ngai, Lok Lam

AU - Bachas, Costa

AU - Kelder, Angèle

AU - Scholten, Willemijn J

AU - Gradowska, Patrycja

AU - Arena, Valentina

AU - João Simione, Anderson

AU - Maurillo, Luca

AU - Venditti, Adriano

AU - Löwenberg, Bob

AU - Ossenkoppele, Gert J

AU - de Leeuw, David C

AU - Ikoma-Colturato, Maura R V

AU - Buccisano, Francesco

AU - Cloos, Jacqueline

PY - 2025/12/10

Y1 - 2025/12/10

UR - https://www.scopus.com/pages/publications/105024719781

U2 - 10.1038/s41375-025-02825-x

DO - 10.1038/s41375-025-02825-x

M3 - Article

C2 - 41372597

SN - 0887-6924

JO - Leukemia

JF - Leukemia

ER -

Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia

UN SDGs

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