Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy

Evgeny V. Fominskiy; Anna Mara Scandroglio; Giacomo Monti; Maria Grazia Calabrò; Giovanni Landoni; Antonio Dell'Acqua; Luigi Beretta; Elena Moizo; Alfredo Ravizza; Fabrizio Monaco; Corrado Campochiaro; Marina Pieri; Maria Luisa Azzolini; Giovanni Borghi; Martina Crivellari; Caterina Conte; Cristina Mattioli; Paolo Silvani; Milena Mucci; Stefano Turi; Stefano Tentori; Martina Baiardo Redaelli; Marianna Sartorelli; Piera Angelillo; Alessandro Belletti; Pasquale Nardelli; Francesco Giuseppe Nisi; Gabriele Valsecchi; Cristina Barberio; Fabio Ciceri; Ary Serpa Neto; Lorenzo Dagna; Rinaldo Bellomo; Alberto Zangrillo

doi:10.1159/000508657

Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy

Evgeny V. Fominskiy
, Anna Mara Scandroglio
, Giacomo Monti
, Maria Grazia Calabrò
, Giovanni Landoni^*
, Antonio Dell'Acqua
, Luigi Beretta
, Elena Moizo
, Alfredo Ravizza
, Fabrizio Monaco
, Corrado Campochiaro
, Marina Pieri
, Maria Luisa Azzolini
, Giovanni Borghi
, Martina Crivellari
, Caterina Conte
, Cristina Mattioli
, Paolo Silvani
, Milena Mucci
, Stefano Turi

Stefano Tentori, Martina Baiardo Redaelli, Marianna Sartorelli, Piera Angelillo, Alessandro Belletti, Pasquale Nardelli, Francesco Giuseppe Nisi, Gabriele Valsecchi, Cristina Barberio, Fabio Ciceri, Ary Serpa Neto, Lorenzo Dagna, Rinaldo Bellomo, Alberto Zangrillo

^*Corresponding author for this work

IRCCS Ospedale San Raffaele
Vita-Salute San Raffaele University
Monash University
Hospital Israelita Albert Einstein
University of Melbourne
Royal Melbourne Hospital

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.

Original language	English
Pages (from-to)	102-109
Number of pages	8
Journal	Blood purification
Volume	50
Issue number	1
DOIs	https://doi.org/10.1159/000508657
Publication status	Published - Jan 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute kidney injury
Coronavirus
Coronavirus disease 2019
Critical care
Renal replacement therapy

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10.1159/000508657

Prevalence-characteristics-risk-factors-and-outcomes-of-invasively-ventilated-covid-19-patients-with-acute-kidney-inj.pdfFinal published version, 334 KBLicence: CC BY

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445373

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Fominskiy, E. V., Scandroglio, A. M., Monti, G., Calabrò, M. G., Landoni, G., Dell'Acqua, A., Beretta, L., Moizo, E., Ravizza, A., Monaco, F., Campochiaro, C., Pieri, M., Azzolini, M. L., Borghi, G., Crivellari, M., Conte, C., Mattioli, C., Silvani, P., Mucci, M., ... Zangrillo, A. (2021). Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy. Blood purification, 50(1), 102-109. https://doi.org/10.1159/000508657

@article{47d082ae39c04645a92d847fb150f285,

title = "Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy",

abstract = "Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0\%) developed AKI and 17 (17.7\%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8\%]), while 15 (20.8\%) developed stage 2 AKI and 24 (33.4\%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9\% for AKI and 52.9\% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.",

keywords = "Acute kidney injury, Coronavirus, Coronavirus disease 2019, Critical care, Renal replacement therapy",

author = "Fominskiy, \{Evgeny V.\} and Scandroglio, \{Anna Mara\} and Giacomo Monti and Calabr{\`o}, \{Maria Grazia\} and Giovanni Landoni and Antonio Dell'Acqua and Luigi Beretta and Elena Moizo and Alfredo Ravizza and Fabrizio Monaco and Corrado Campochiaro and Marina Pieri and Azzolini, \{Maria Luisa\} and Giovanni Borghi and Martina Crivellari and Caterina Conte and Cristina Mattioli and Paolo Silvani and Milena Mucci and Stefano Turi and Stefano Tentori and \{Baiardo Redaelli\}, Martina and Marianna Sartorelli and Piera Angelillo and Alessandro Belletti and Pasquale Nardelli and Nisi, \{Francesco Giuseppe\} and Gabriele Valsecchi and Cristina Barberio and Fabio Ciceri and \{Serpa Neto\}, Ary and Lorenzo Dagna and Rinaldo Bellomo and Alberto Zangrillo",

year = "2021",

month = jan,

doi = "10.1159/000508657",

language = "English",

volume = "50",

pages = "102--109",

journal = "Blood purification",

issn = "0253-5068",

publisher = "S. Karger AG",

number = "1",

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Fominskiy, EV, Scandroglio, AM, Monti, G, Calabrò, MG, Landoni, G, Dell'Acqua, A, Beretta, L, Moizo, E, Ravizza, A, Monaco, F, Campochiaro, C, Pieri, M, Azzolini, ML, Borghi, G, Crivellari, M, Conte, C, Mattioli, C, Silvani, P, Mucci, M, Turi, S, Tentori, S, Baiardo Redaelli, M, Sartorelli, M, Angelillo, P, Belletti, A, Nardelli, P, Nisi, FG, Valsecchi, G, Barberio, C, Ciceri, F, Serpa Neto, A, Dagna, L, Bellomo, R & Zangrillo, A 2021, 'Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy', Blood purification, vol. 50, no. 1, pp. 102-109. https://doi.org/10.1159/000508657

TY - JOUR

T1 - Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy

AU - Fominskiy, Evgeny V.

AU - Scandroglio, Anna Mara

AU - Monti, Giacomo

AU - Calabrò, Maria Grazia

AU - Landoni, Giovanni

AU - Dell'Acqua, Antonio

AU - Beretta, Luigi

AU - Moizo, Elena

AU - Ravizza, Alfredo

AU - Monaco, Fabrizio

AU - Campochiaro, Corrado

AU - Pieri, Marina

AU - Azzolini, Maria Luisa

AU - Borghi, Giovanni

AU - Crivellari, Martina

AU - Conte, Caterina

AU - Mattioli, Cristina

AU - Silvani, Paolo

AU - Mucci, Milena

AU - Turi, Stefano

AU - Tentori, Stefano

AU - Baiardo Redaelli, Martina

AU - Sartorelli, Marianna

AU - Angelillo, Piera

AU - Belletti, Alessandro

AU - Nardelli, Pasquale

AU - Nisi, Francesco Giuseppe

AU - Valsecchi, Gabriele

AU - Barberio, Cristina

AU - Ciceri, Fabio

AU - Serpa Neto, Ary

AU - Dagna, Lorenzo

AU - Bellomo, Rinaldo

AU - Zangrillo, Alberto

PY - 2021/1

Y1 - 2021/1

N2 - Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.

AB - Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.

KW - Acute kidney injury

KW - Coronavirus

KW - Coronavirus disease 2019

KW - Critical care

KW - Renal replacement therapy

UR - https://www.scopus.com/pages/publications/85088370799

U2 - 10.1159/000508657

DO - 10.1159/000508657

M3 - Article

C2 - 32659757

SN - 0253-5068

VL - 50

SP - 102

EP - 109

JO - Blood purification

JF - Blood purification

IS - 1

ER -

Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy

Abstract

UN SDGs

Keywords

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