Preimplantation genetic screening

Sjoerd Repping; Sebastiaan Mastenbroek; Paul N. Scriven

doi:10.1007/978-1-4471-2948-6_16

Preimplantation genetic screening

Sjoerd Repping
, Sebastiaan Mastenbroek^*
, Paul N. Scriven

^*Corresponding author for this work

Guy's and St Thomas' NHS Foundation Trust
King's College London

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Chromosome aneuploidy is naturally occurring, typically sporadic and generally leads to non-viable offspring. The use of PGS has the potential to select the best embryos for transfer and reduce the risk of losing a much wanted pregnancy. However there is no high-level clinical evidence from randomized control trials to demonstrate a beneficial effect of PGS on the live birth rate after IVF, and for women of advanced age, PGS using cleavage stage biopsy and FISH may lead to a significant decrease in live birth rates. Technical limitations and chromosomal mosaicism confound the effectiveness of PGS, but a test that could identify aneuploidy with 100 % accuracy would be a significant advance; no such test has yet been developed. New approaches in the application of PGS should be evaluated carefully before their introduction into clinical practice.

Original language	English
Title of host publication	Preimplantation Genetic Diagnosis in Clinical Practice
Publisher	Springer-Verlag London Ltd
Pages	175-185
Number of pages	11
ISBN (Electronic)	9781447129486
ISBN (Print)	9781447129479
DOIs	https://doi.org/10.1007/978-1-4471-2948-6_16
Publication status	Published - 1 Jan 2014

Access to Document

10.1007/978-1-4471-2948-6_16

Cite this

@inbook{d4768a3cbd53469181151b1daefd2d62,

title = "Preimplantation genetic screening",

abstract = "Chromosome aneuploidy is naturally occurring, typically sporadic and generally leads to non-viable offspring. The use of PGS has the potential to select the best embryos for transfer and reduce the risk of losing a much wanted pregnancy. However there is no high-level clinical evidence from randomized control trials to demonstrate a beneficial effect of PGS on the live birth rate after IVF, and for women of advanced age, PGS using cleavage stage biopsy and FISH may lead to a significant decrease in live birth rates. Technical limitations and chromosomal mosaicism confound the effectiveness of PGS, but a test that could identify aneuploidy with 100 \% accuracy would be a significant advance; no such test has yet been developed. New approaches in the application of PGS should be evaluated carefully before their introduction into clinical practice.",

author = "Sjoerd Repping and Sebastiaan Mastenbroek and Scriven, \{Paul N.\}",

note = "Publisher Copyright: {\textcopyright} Springer-Verlag London 2014.",

year = "2014",

month = jan,

day = "1",

doi = "10.1007/978-1-4471-2948-6\_16",

language = "English",

isbn = "9781447129479",

pages = "175--185",

booktitle = "Preimplantation Genetic Diagnosis in Clinical Practice",

publisher = "Springer-Verlag London Ltd",

}

TY - CHAP

T1 - Preimplantation genetic screening

AU - Repping, Sjoerd

AU - Mastenbroek, Sebastiaan

AU - Scriven, Paul N.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Chromosome aneuploidy is naturally occurring, typically sporadic and generally leads to non-viable offspring. The use of PGS has the potential to select the best embryos for transfer and reduce the risk of losing a much wanted pregnancy. However there is no high-level clinical evidence from randomized control trials to demonstrate a beneficial effect of PGS on the live birth rate after IVF, and for women of advanced age, PGS using cleavage stage biopsy and FISH may lead to a significant decrease in live birth rates. Technical limitations and chromosomal mosaicism confound the effectiveness of PGS, but a test that could identify aneuploidy with 100 % accuracy would be a significant advance; no such test has yet been developed. New approaches in the application of PGS should be evaluated carefully before their introduction into clinical practice.

AB - Chromosome aneuploidy is naturally occurring, typically sporadic and generally leads to non-viable offspring. The use of PGS has the potential to select the best embryos for transfer and reduce the risk of losing a much wanted pregnancy. However there is no high-level clinical evidence from randomized control trials to demonstrate a beneficial effect of PGS on the live birth rate after IVF, and for women of advanced age, PGS using cleavage stage biopsy and FISH may lead to a significant decrease in live birth rates. Technical limitations and chromosomal mosaicism confound the effectiveness of PGS, but a test that could identify aneuploidy with 100 % accuracy would be a significant advance; no such test has yet been developed. New approaches in the application of PGS should be evaluated carefully before their introduction into clinical practice.

UR - https://www.scopus.com/pages/publications/84955357114

U2 - 10.1007/978-1-4471-2948-6_16

DO - 10.1007/978-1-4471-2948-6_16

M3 - Chapter

AN - SCOPUS:84955357114

SN - 9781447129479

SP - 175

EP - 185

BT - Preimplantation Genetic Diagnosis in Clinical Practice

PB - Springer-Verlag London Ltd

ER -

Preimplantation genetic screening

Abstract

Access to Document

Other files and links

Fingerprint

Cite this