Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns

Norina N Gassmann; Hugo A van Elteren; Tom G Goos; Claudia R Morales; Maria Rivera-Ch; Daniel S Martin; Patricia Cabala Peralta; Agustin Passano Del Carpio; Saul Aranibar Machaca; Luis Huicho; Irwin K M Reiss; Max Gassmann; Rogier C J de Jonge

doi:10.1152/japplphysiol.00561.2016

Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns

Norina N Gassmann
, Hugo A van Elteren
, Tom G Goos
, Claudia R Morales
, Maria Rivera-Ch
, Daniel S Martin
, Patricia Cabala Peralta
, Agustin Passano Del Carpio
, Saul Aranibar Machaca
, Luis Huicho
, Irwin K M Reiss
, Max Gassmann
, Rogier C J de Jonge

Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), Medical Faculty, University of Zurich, Zurich, Switzerland; Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands;
Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands;
Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands; Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands;
Laboratory of Adaptation to High Altitude, Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru;
Laboratory of Adaptation to High Altitude, Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru; Center of Research for Integral and Sustainable Development (CIDIS), UPCH, Lima, Peru;
University College London Centre for Altitude Space and Extreme Environment Medicine, Univesity College London Hospital (UCLH) National Institute for Health Research (NIHR) Biomedical Research Centre, Institute of Sport and Exercise Health, London, United Kingdom;
Hospital III Puno EsSalud, Puno, Peru; and.
Center of Research for Integral and Sustainable Development (CIDIS), UPCH, Lima, Peru; School of Medicine, UPCH, Lima, Peru.
Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), Medical Faculty, University of Zurich, Zurich, Switzerland; School of Medicine, UPCH, Lima, Peru [email protected].

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healthy term newborns in Puno, Peru (3,840 m) were compared with sea-level controls. Pre- and postductal arterial oxygen saturation (SpO2) was determined. Cerebral and calf muscle regional tissue oxygenation was measured using near infrared spectroscopy (NIRS). Skin microcirculation was noninvasively measured using incident dark field imaging. Pre- and postductal SpO2 in Peruvian babies was 88.1 and 88.4%, respectively, which was 10.4 and 9.7% lower than in newborns at sea level (P < 0.001). Cerebral and regional oxygen saturation was significantly lower in the Peruvian newborns (cerebral: 71.0 vs. 74.9%; regional: 68.5 vs. 76.0%, P < 0.001). Transcutaneously measured total vessel density in the Peruvian newborns was 14% higher than that in the newborns born at sea level (29.7 vs. 26.0 mm/mm(2); P ≤ 0.001). This study demonstrates that microvascular vessel density in neonates born to mothers living at high altitude is higher than that in neonates born at sea level.

Original language	English
Pages (from-to)	709-15
Number of pages	7
Journal	Journal of applied physiology (Bethesda, Md. : 1985)
Volume	121
Issue number	3
DOIs	https://doi.org/10.1152/japplphysiol.00561.2016
Publication status	Published - 1 Sept 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acclimatization/physiology
Adult
Altitude
Female
Humans
Infant, Newborn/physiology
Male
Microcirculation/physiology
Microvessels/anatomy & histology
Peru
Pregnancy/physiology
Prospective Studies
Young Adult

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Pregnancy-at-high-altitude-in-the-andes-leads-to-increased-total-vessel-density-in-healthy-newborns.pdfFinal published version, 376 KBLicence: Taverne

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Gassmann, N. N., van Elteren, H. A., Goos, T. G., Morales, C. R., Rivera-Ch, M., Martin, D. S., Cabala Peralta, P., Passano Del Carpio, A., Aranibar Machaca, S., Huicho, L., Reiss, I. K. M., Gassmann, M., & de Jonge, R. C. J. (2016). Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns. Journal of applied physiology (Bethesda, Md. : 1985), 121(3), 709-15. https://doi.org/10.1152/japplphysiol.00561.2016

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title = "Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns",

abstract = "The developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healthy term newborns in Puno, Peru (3,840 m) were compared with sea-level controls. Pre- and postductal arterial oxygen saturation (SpO2) was determined. Cerebral and calf muscle regional tissue oxygenation was measured using near infrared spectroscopy (NIRS). Skin microcirculation was noninvasively measured using incident dark field imaging. Pre- and postductal SpO2 in Peruvian babies was 88.1 and 88.4\%, respectively, which was 10.4 and 9.7\% lower than in newborns at sea level (P < 0.001). Cerebral and regional oxygen saturation was significantly lower in the Peruvian newborns (cerebral: 71.0 vs. 74.9\%; regional: 68.5 vs. 76.0\%, P < 0.001). Transcutaneously measured total vessel density in the Peruvian newborns was 14\% higher than that in the newborns born at sea level (29.7 vs. 26.0 mm/mm(2); P ≤ 0.001). This study demonstrates that microvascular vessel density in neonates born to mothers living at high altitude is higher than that in neonates born at sea level. ",

keywords = "Acclimatization/physiology, Adult, Altitude, Female, Humans, Infant, Newborn/physiology, Male, Microcirculation/physiology, Microvessels/anatomy \& histology, Peru, Pregnancy/physiology, Prospective Studies, Young Adult",

author = "Gassmann, \{Norina N\} and \{van Elteren\}, \{Hugo A\} and Goos, \{Tom G\} and Morales, \{Claudia R\} and Maria Rivera-Ch and Martin, \{Daniel S\} and \{Cabala Peralta\}, Patricia and \{Passano Del Carpio\}, Agustin and \{Aranibar Machaca\}, Saul and Luis Huicho and Reiss, \{Irwin K M\} and Max Gassmann and \{de Jonge\}, \{Rogier C J\}",

year = "2016",

month = sep,

day = "1",

doi = "10.1152/japplphysiol.00561.2016",

language = "English",

volume = "121",

pages = "709--15",

journal = "Journal of applied physiology (Bethesda, Md. : 1985)",

issn = "0161-7567",

publisher = "American Physiological Society",

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}

Gassmann, NN, van Elteren, HA, Goos, TG, Morales, CR, Rivera-Ch, M, Martin, DS, Cabala Peralta, P, Passano Del Carpio, A, Aranibar Machaca, S, Huicho, L, Reiss, IKM, Gassmann, M & de Jonge, RCJ 2016, 'Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns', Journal of applied physiology (Bethesda, Md. : 1985), vol. 121, no. 3, pp. 709-15. https://doi.org/10.1152/japplphysiol.00561.2016

TY - JOUR

T1 - Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns

AU - Gassmann, Norina N

AU - van Elteren, Hugo A

AU - Goos, Tom G

AU - Morales, Claudia R

AU - Rivera-Ch, Maria

AU - Martin, Daniel S

AU - Cabala Peralta, Patricia

AU - Passano Del Carpio, Agustin

AU - Aranibar Machaca, Saul

AU - Huicho, Luis

AU - Reiss, Irwin K M

AU - Gassmann, Max

AU - de Jonge, Rogier C J

PY - 2016/9/1

Y1 - 2016/9/1

N2 - The developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healthy term newborns in Puno, Peru (3,840 m) were compared with sea-level controls. Pre- and postductal arterial oxygen saturation (SpO2) was determined. Cerebral and calf muscle regional tissue oxygenation was measured using near infrared spectroscopy (NIRS). Skin microcirculation was noninvasively measured using incident dark field imaging. Pre- and postductal SpO2 in Peruvian babies was 88.1 and 88.4%, respectively, which was 10.4 and 9.7% lower than in newborns at sea level (P < 0.001). Cerebral and regional oxygen saturation was significantly lower in the Peruvian newborns (cerebral: 71.0 vs. 74.9%; regional: 68.5 vs. 76.0%, P < 0.001). Transcutaneously measured total vessel density in the Peruvian newborns was 14% higher than that in the newborns born at sea level (29.7 vs. 26.0 mm/mm(2); P ≤ 0.001). This study demonstrates that microvascular vessel density in neonates born to mothers living at high altitude is higher than that in neonates born at sea level.

AB - The developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healthy term newborns in Puno, Peru (3,840 m) were compared with sea-level controls. Pre- and postductal arterial oxygen saturation (SpO2) was determined. Cerebral and calf muscle regional tissue oxygenation was measured using near infrared spectroscopy (NIRS). Skin microcirculation was noninvasively measured using incident dark field imaging. Pre- and postductal SpO2 in Peruvian babies was 88.1 and 88.4%, respectively, which was 10.4 and 9.7% lower than in newborns at sea level (P < 0.001). Cerebral and regional oxygen saturation was significantly lower in the Peruvian newborns (cerebral: 71.0 vs. 74.9%; regional: 68.5 vs. 76.0%, P < 0.001). Transcutaneously measured total vessel density in the Peruvian newborns was 14% higher than that in the newborns born at sea level (29.7 vs. 26.0 mm/mm(2); P ≤ 0.001). This study demonstrates that microvascular vessel density in neonates born to mothers living at high altitude is higher than that in neonates born at sea level.

KW - Acclimatization/physiology

KW - Adult

KW - Altitude

KW - Female

KW - Humans

KW - Infant, Newborn/physiology

KW - Male

KW - Microcirculation/physiology

KW - Microvessels/anatomy & histology

KW - Peru

KW - Pregnancy/physiology

KW - Prospective Studies

KW - Young Adult

U2 - 10.1152/japplphysiol.00561.2016

DO - 10.1152/japplphysiol.00561.2016

M3 - Article

SN - 0161-7567

VL - 121

SP - 709

EP - 715

JO - Journal of applied physiology (Bethesda, Md. : 1985)

JF - Journal of applied physiology (Bethesda, Md. : 1985)

IS - 3

ER -

Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns

Abstract

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Keywords

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