TY - JOUR
T1 - Practical Guidelines for the Treatment of Gestational Trophoblastic Disease
T2 - Collaboration of the European Organisation for the Treatment of Trophoblastic Disease (EOTTD)-European Society of Gynaecologic Oncology (ESGO)-Gynecologic Cancer InterGroup (GCIG)-International Society for the Study of Trophoblastic Diseases (ISSTD)
AU - Lok, Christianne
AU - van Trommel, Nienke
AU - Braicu, Elena Ioana
AU - Planchamp, Francois
AU - Berkowitz, Ross
AU - Seckl, Michael
AU - Baas, Inge O.
AU - Bergamini, Alice
AU - Abreu, Miguel Henriques
AU - Bolze, Pierre-Adrien
AU - Bouchard-Fortier, Genevieve
AU - Braga, Antonio
AU - Cagayan, Maria Stephanie Fay S.
AU - Casado, Antonio
AU - Choi, Min Chul
AU - Coulter, John
AU - Elias, Kevin
AU - Elmalik, Hind H.
AU - Garrett, Andrea
AU - Ghorani, Ehsan
AU - Gmur, Andrea
AU - Goffin, Frederic
AU - Golfier, Francois
AU - Horowitz, Neil
AU - Joneborg, Ulrika
AU - Kaur, Baljeet
AU - Kipkirui, Philip Tonui
AU - Korach, Jacob
AU - Lu, Xin
AU - Maesta, Izildinha
AU - Mangili, Giorgia
AU - Marquina, Gloria
AU - Massardier, Jerome
AU - Ngan, Hextan Y. S.
AU - Osborne, Ray
AU - Ottevanger, Nelleke P. B.
AU - Ozalp, Sinan
AU - Sarwar, Naveed
AU - Sekharan, Paradan K.
AU - Siegenthaler, Franziska
AU - Solheim, Olesya
AU - Sunde, Lone
AU - Sweep, Fred C. G. J.
AU - Szewczyk, Grzegorz
AU - Undurraga, Manuela
AU - Wallin, Emelie
AU - Winter, Matthew C.
AU - Yamamoto, Eiko
AU - You, Benoit
AU - Wallin, Emelie
AU - Westermann, Anneke
AU - Xiang, Yang
AU - EOTTD-ESGO-GCIG-ISSTD Guideline Committee
AU - Zapardiel, Ignacio
N1 - Publisher Copyright:
© 2025 by American Society of Clinical Oncology.
PY - 2025/6/20
Y1 - 2025/6/20
N2 - Gestational trophoblastic diseases (GTDs) are a group of pregnancy-related premalignant and malignant diseases with generally a favorable prognosis when treated adequately. Many different treatment protocols exist worldwide. To our knowledge, this is the first set of global consensus-based guidelines for GTD. Four international organizations (European Organisation for the Treatment of Trophoblastic Diseases, European Society of Gynecologic Oncology, Gynecologic Cancer Intergroup, and International Society for the Study of Trophoblastic Diseases) delegated 53 expert GTD clinicians from 31 countries who formulated nine consensus-based definitions and the minimum criteria required to be a GTD center. Furthermore, 18 flow diagrams were developed to diagnose, treat, and follow up all forms of primary or recurrent GTD. The definitions and flow diagrams were drafted and adapted in consecutive (online) meetings until consensus was reached followed by an external review process. Here, the final guidelines are presented together with the available supporting evidence from the literature.
AB - Gestational trophoblastic diseases (GTDs) are a group of pregnancy-related premalignant and malignant diseases with generally a favorable prognosis when treated adequately. Many different treatment protocols exist worldwide. To our knowledge, this is the first set of global consensus-based guidelines for GTD. Four international organizations (European Organisation for the Treatment of Trophoblastic Diseases, European Society of Gynecologic Oncology, Gynecologic Cancer Intergroup, and International Society for the Study of Trophoblastic Diseases) delegated 53 expert GTD clinicians from 31 countries who formulated nine consensus-based definitions and the minimum criteria required to be a GTD center. Furthermore, 18 flow diagrams were developed to diagnose, treat, and follow up all forms of primary or recurrent GTD. The definitions and flow diagrams were drafted and adapted in consecutive (online) meetings until consensus was reached followed by an external review process. Here, the final guidelines are presented together with the available supporting evidence from the literature.
UR - https://www.scopus.com/pages/publications/105005462782
U2 - 10.1200/JCO-24-02326
DO - 10.1200/JCO-24-02326
M3 - Article
C2 - 40359461
SN - 0732-183X
VL - 43
SP - 2119
EP - 2128
JO - Journal of clinical oncology
JF - Journal of clinical oncology
IS - 18
M1 - JCO-24-02326
ER -
SDG 3 Good Health and Well-being