Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review

Coen K. M. Boerhout; Marcel A. M. Beijk; Peter Damman; Jan J. Piek; Tim P. van de Hoef

doi:10.4070/kcj.2023.0109

Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review

Coen K. M. Boerhout
, Marcel A. M. Beijk
, Peter Damman
, Jan J. Piek
, Tim P. van de Hoef^*

^*Corresponding author for this work

Radboud University Nijmegen
University Medical Center Utrecht

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.

Original language	English
Article number	e52
Journal	Korean Circulation Journal
Volume	53
DOIs	https://doi.org/10.4070/kcj.2023.0109
Publication status	Published - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ANOCA
Abnormal vasodilatory capacity
Coronary microvascular disease
Vasospasm

Access to Document

10.4070/kcj.2023.0109

Cite this

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title = "Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review",

abstract = "Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.",

keywords = "ANOCA, Abnormal vasodilatory capacity, Coronary microvascular disease, Vasospasm",

author = "Boerhout, \{Coen K. M.\} and Beijk, \{Marcel A. M.\} and Peter Damman and Piek, \{Jan J.\} and \{van de Hoef\}, \{Tim P.\}",

note = "Funding Information: The authors received no financial support for the research, authorship, and/or publication of this article. Publisher Copyright: {\textcopyright} 2023. The Korean Society of Cardiology.",

year = "2023",

doi = "10.4070/kcj.2023.0109",

language = "English",

volume = "53",

journal = "Korean Circulation Journal",

issn = "1738-5520",

publisher = "Korean Society of Cardiology",

}

TY - JOUR

T1 - Practical Approach for Angina and Non-Obstructive Coronary Arteries

T2 - A State-of-the-Art Review

AU - Boerhout, Coen K. M.

AU - Beijk, Marcel A. M.

AU - Damman, Peter

AU - Piek, Jan J.

AU - van de Hoef, Tim P.

PY - 2023

Y1 - 2023

N2 - Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.

AB - Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.

KW - ANOCA

KW - Abnormal vasodilatory capacity

KW - Coronary microvascular disease

KW - Vasospasm

UR - https://www.scopus.com/pages/publications/85166640588

U2 - 10.4070/kcj.2023.0109

DO - 10.4070/kcj.2023.0109

M3 - Article

C2 - 37525496

SN - 1738-5520

VL - 53

JO - Korean Circulation Journal

JF - Korean Circulation Journal

M1 - e52

ER -

Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review

Abstract

UN SDGs

Keywords

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