Potential for improvement of docetaxel-based chemotherapy: a pharmacological review

F. K. Engels; A. Sparreboom; R. A. A. Mathot; J. Verweij

doi:10.1038/sj.bjc.6602698

Potential for improvement of docetaxel-based chemotherapy: a pharmacological review

F. K. Engels
, A. Sparreboom
, R. A. A. Mathot
, J. Verweij

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes

Original language	English
Pages (from-to)	173-177
Journal	British journal of cancer
Volume	93
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6602698
Publication status	Published - 2005

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/sj.bjc.6602698

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title = "Potential for improvement of docetaxel-based chemotherapy: a pharmacological review",

abstract = "Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes",

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AB - Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes

U2 - 10.1038/sj.bjc.6602698

DO - 10.1038/sj.bjc.6602698

M3 - Review article

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SP - 173

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JO - British journal of cancer

JF - British journal of cancer

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Potential for improvement of docetaxel-based chemotherapy: a pharmacological review

Abstract

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