Ploidy status and the response of T1 glottic carcinoma to radiotherapy

H. A. Westerbeek; W. J. Mooi; F. J. Hilgers; G. Baris; A. C. Begg; A. J. Balm

doi:10.1111/j.1365-2273.1993.tb00537.x

Ploidy status and the response of T1 glottic carcinoma to radiotherapy

H. A. Westerbeek, W. J. Mooi, F. J. Hilgers, G. Baris, A. C. Begg, A. J. Balm

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Abstract

Flow cytometric DNA ploidy measurements were performed on formalin fixed paraffin embedded tumour specimens from patients with a T1 glottic laryngeal carcinoma in order to evaluate the role of DNA content in relation to local control. From 1980 to 1987, a consecutive series of 90 patients with a T1 glottic laryngeal carcinoma were treated by radiotherapy with curative intent. Biopsies from 44 of these patients were readily available for DNA flow cytometry. In this group aneuploidy was associated with a significantly higher risk (P = 0.018) of local recurrence within 2 years after completion of radiotherapy (38% vs. 9% in the diploid group)

Original language	English
Pages (from-to)	98-101
Journal	Clinical otolaryngology and allied sciences
Volume	18
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2273.1993.tb00537.x
Publication status	Published - 1993

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10.1111/j.1365-2273.1993.tb00537.x

Cite this

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title = "Ploidy status and the response of T1 glottic carcinoma to radiotherapy",

abstract = "Flow cytometric DNA ploidy measurements were performed on formalin fixed paraffin embedded tumour specimens from patients with a T1 glottic laryngeal carcinoma in order to evaluate the role of DNA content in relation to local control. From 1980 to 1987, a consecutive series of 90 patients with a T1 glottic laryngeal carcinoma were treated by radiotherapy with curative intent. Biopsies from 44 of these patients were readily available for DNA flow cytometry. In this group aneuploidy was associated with a significantly higher risk (P = 0.018) of local recurrence within 2 years after completion of radiotherapy (38% vs. 9% in the diploid group)",

author = "Westerbeek, {H. A.} and Mooi, {W. J.} and Hilgers, {F. J.} and G. Baris and Begg, {A. C.} and Balm, {A. J.}",

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AU - Westerbeek, H. A.

AU - Mooi, W. J.

AU - Hilgers, F. J.

AU - Baris, G.

AU - Begg, A. C.

AU - Balm, A. J.

PY - 1993

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AB - Flow cytometric DNA ploidy measurements were performed on formalin fixed paraffin embedded tumour specimens from patients with a T1 glottic laryngeal carcinoma in order to evaluate the role of DNA content in relation to local control. From 1980 to 1987, a consecutive series of 90 patients with a T1 glottic laryngeal carcinoma were treated by radiotherapy with curative intent. Biopsies from 44 of these patients were readily available for DNA flow cytometry. In this group aneuploidy was associated with a significantly higher risk (P = 0.018) of local recurrence within 2 years after completion of radiotherapy (38% vs. 9% in the diploid group)

U2 - 10.1111/j.1365-2273.1993.tb00537.x

DO - 10.1111/j.1365-2273.1993.tb00537.x

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