Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria

Theodora A. M. Claushuis; Alex F. de Vos; Bernard Nieswandt; Louis Boon; Joris J. T. H. Roelofs; Onno J. de Boer; Cornelis van 't Veer; Tom van der Poll

doi:10.1182/blood-2017-06-788067

Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria

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Abstract

-/-and wild-type mice. CLEC2 depletion did not affect any of the responses during pneumonia. These results suggest that platelet GPVI, but not CLEC2, contributes to local host defense during pneumonia-derived sepsis by enhancing leukocyte function

Original language	English
Pages (from-to)	864-876
Journal	Blood
Volume	131
Issue number	8
Early online date	2017
DOIs	https://doi.org/10.1182/blood-2017-06-788067
Publication status	Published - 2018

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SDG 3 Good Health and Well-being

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@article{6db903a6a1494b9ba4d7d2ef6d22b72c,

title = "Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria",

abstract = "-/-and wild-type mice. CLEC2 depletion did not affect any of the responses during pneumonia. These results suggest that platelet GPVI, but not CLEC2, contributes to local host defense during pneumonia-derived sepsis by enhancing leukocyte function",

author = "Claushuis, \{Theodora A. M.\} and \{de Vos\}, \{Alex F.\} and Bernard Nieswandt and Louis Boon and Roelofs, \{Joris J. T. H.\} and \{de Boer\}, \{Onno J.\} and \{van 't Veer\}, Cornelis and \{van der Poll\}, Tom",

year = "2018",

doi = "10.1182/blood-2017-06-788067",

language = "English",

volume = "131",

pages = "864--876",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "8",

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TY - JOUR

T1 - Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria

AU - Claushuis, Theodora A. M.

AU - de Vos, Alex F.

AU - Nieswandt, Bernard

AU - Boon, Louis

AU - Roelofs, Joris J. T. H.

AU - de Boer, Onno J.

AU - van 't Veer, Cornelis

AU - van der Poll, Tom

PY - 2018

Y1 - 2018

N2 - -/-and wild-type mice. CLEC2 depletion did not affect any of the responses during pneumonia. These results suggest that platelet GPVI, but not CLEC2, contributes to local host defense during pneumonia-derived sepsis by enhancing leukocyte function

AB - -/-and wild-type mice. CLEC2 depletion did not affect any of the responses during pneumonia. These results suggest that platelet GPVI, but not CLEC2, contributes to local host defense during pneumonia-derived sepsis by enhancing leukocyte function

U2 - 10.1182/blood-2017-06-788067

DO - 10.1182/blood-2017-06-788067

M3 - Article

C2 - 29187378

SN - 0006-4971

VL - 131

SP - 864

EP - 876

JO - Blood

JF - Blood

IS - 8

ER -

Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria

Abstract

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