Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy

Stefanie Kroeze; Theresa M. Rossouw; Helen C. Steel; Ferdinand W. Wit; Cissy M. Kityo; Margaret Siwale; Sulaimon Akanmu; Kishor Mandaliya; Marleen de Jager; Pascale Ondoa; Peter Reiss; Tobias F. Rinke de Wit; Neeltje A. Kootstra; Raph L. Hamers

doi:10.1093/infdis/jiaa787

Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy

Stefanie Kroeze
, Theresa M. Rossouw
, Helen C. Steel
, Ferdinand W. Wit
, Cissy M. Kityo
, Margaret Siwale
, Sulaimon Akanmu
, Kishor Mandaliya
, Marleen de Jager
, Pascale Ondoa
, Peter Reiss
, Tobias F. Rinke de Wit
, Neeltje A. Kootstra
, Raph L. Hamers

Amsterdam Institute for Global Health and Development
Amsterdam UMC - University of Amsterdam
University of Pretoria
HIV Monitoring Foundation, Amsterdam, Netherlands
Joint Clinical Research Center
Lusaka Trust Hospital, Zambia.
University of Lagos
Coast General Teaching and Referral Hospital
Muelmed Hospital, Pretoria, South Africa
African Society for Laboratory Medicine, Addis Ababa, 5487, Ethiopia;
Emerging Infections Group, Oxford University Clinical Research Unit, Ho Chi Minh city, Vietnam
University of Oxford

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This multicountry prospective study investigated whether persistent systemic inflammation, measured by 8 plasma biomarkers, in HIV-1-infected Africans during suppressive antiretroviral therapy (ART) (viral load <50 copies/mL), was associated with CD4+ T-cell recovery and viral rebound (>1000 copies/mL) during long-term treatment. On-ART sCD14 and C-reactive protein concentrations were inversely associated with subsequent CD4+ T-cell counts. Risk of viral rebound was increased for participants with higher on-ART CXCL10 concentrations and reduced for those with a greater sCD163 decline during the first year of ART. Persistent systemic inflammation predicted CD4+ T-cell recovery and viral rebound, warranting further mechanistic research in relation to clinical outcomes.

Original language	English
Pages (from-to)	673-678
Number of pages	6
Journal	Journal of infectious diseases
Volume	224
Issue number	4
Early online date	29 Dec 2020
DOIs	https://doi.org/10.1093/infdis/jiaa787
Publication status	Published - 15 Aug 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV-1
antiretroviral therapy
biomarkers
cytokines
immune activation
inflammation
sub-Saharan Africa

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Kroeze, S., Rossouw, T. M., Steel, H. C., Wit, F. W., Kityo, C. M., Siwale, M., Akanmu, S., Mandaliya, K., de Jager, M., Ondoa, P., Reiss, P., Rinke de Wit, T. F., Kootstra, N. A., & Hamers, R. L. (2021). Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy. Journal of infectious diseases, 224(4), 673-678. https://doi.org/10.1093/infdis/jiaa787

@article{2bd99e89dcbf4f3db66cf4b694cfad7f,

title = "Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy",

abstract = "This multicountry prospective study investigated whether persistent systemic inflammation, measured by 8 plasma biomarkers, in HIV-1-infected Africans during suppressive antiretroviral therapy (ART) (viral load <50 copies/mL), was associated with CD4+ T-cell recovery and viral rebound (>1000 copies/mL) during long-term treatment. On-ART sCD14 and C-reactive protein concentrations were inversely associated with subsequent CD4+ T-cell counts. Risk of viral rebound was increased for participants with higher on-ART CXCL10 concentrations and reduced for those with a greater sCD163 decline during the first year of ART. Persistent systemic inflammation predicted CD4+ T-cell recovery and viral rebound, warranting further mechanistic research in relation to clinical outcomes.",

keywords = "HIV-1, antiretroviral therapy, biomarkers, cytokines, immune activation, inflammation, sub-Saharan Africa",

author = "Stefanie Kroeze and Rossouw, \{Theresa M.\} and Steel, \{Helen C.\} and Wit, \{Ferdinand W.\} and Kityo, \{Cissy M.\} and Margaret Siwale and Sulaimon Akanmu and Kishor Mandaliya and \{de Jager\}, Marleen and Pascale Ondoa and Peter Reiss and \{Rinke de Wit\}, \{Tobias F.\} and Kootstra, \{Neeltje A.\} and Hamers, \{Raph L.\}",

note = "Funding Information: This work was supported by the Netherlands Organization for Scientific Research, Innovational Research Incentives Scheme (grant number 91615036 to R. L. H.). The PanAfrican Studies to Evaluate Resistance (PASER) is an initiative of the Amsterdam Institute for Global Health and Development, supported by the Ministry of Foreign Affairs of The Netherlands and Stichting Aids Fonds (grant number 12454), with additional support from De Grote Onderneming, Heineken Africa Foundation, Jura Foundation, and the Netherlands Organization for Scientific Research through the Netherlands-African Partnership for Capacity Development Clinical Interventions against Poverty-Related Diseases (grant numbers W07.10.101 and W07.10.106). Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].",

year = "2021",

month = aug,

day = "15",

doi = "10.1093/infdis/jiaa787",

language = "English",

volume = "224",

pages = "673--678",

journal = "Journal of infectious diseases",

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Kroeze, S, Rossouw, TM, Steel, HC, Wit, FW, Kityo, CM, Siwale, M, Akanmu, S, Mandaliya, K, de Jager, M, Ondoa, P, Reiss, P , Rinke de Wit, TF , Kootstra, NA & Hamers, RL 2021, 'Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy', Journal of infectious diseases, vol. 224, no. 4, pp. 673-678. https://doi.org/10.1093/infdis/jiaa787

TY - JOUR

T1 - Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy

AU - Kroeze, Stefanie

AU - Rossouw, Theresa M.

AU - Steel, Helen C.

AU - Wit, Ferdinand W.

AU - Kityo, Cissy M.

AU - Siwale, Margaret

AU - Akanmu, Sulaimon

AU - Mandaliya, Kishor

AU - de Jager, Marleen

AU - Ondoa, Pascale

AU - Reiss, Peter

AU - Rinke de Wit, Tobias F.

AU - Kootstra, Neeltje A.

AU - Hamers, Raph L.

N1 - Funding Information: This work was supported by the Netherlands Organization for Scientific Research, Innovational Research Incentives Scheme (grant number 91615036 to R. L. H.). The PanAfrican Studies to Evaluate Resistance (PASER) is an initiative of the Amsterdam Institute for Global Health and Development, supported by the Ministry of Foreign Affairs of The Netherlands and Stichting Aids Fonds (grant number 12454), with additional support from De Grote Onderneming, Heineken Africa Foundation, Jura Foundation, and the Netherlands Organization for Scientific Research through the Netherlands-African Partnership for Capacity Development Clinical Interventions against Poverty-Related Diseases (grant numbers W07.10.101 and W07.10.106). Publisher Copyright: © 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

PY - 2021/8/15

Y1 - 2021/8/15

N2 - This multicountry prospective study investigated whether persistent systemic inflammation, measured by 8 plasma biomarkers, in HIV-1-infected Africans during suppressive antiretroviral therapy (ART) (viral load <50 copies/mL), was associated with CD4+ T-cell recovery and viral rebound (>1000 copies/mL) during long-term treatment. On-ART sCD14 and C-reactive protein concentrations were inversely associated with subsequent CD4+ T-cell counts. Risk of viral rebound was increased for participants with higher on-ART CXCL10 concentrations and reduced for those with a greater sCD163 decline during the first year of ART. Persistent systemic inflammation predicted CD4+ T-cell recovery and viral rebound, warranting further mechanistic research in relation to clinical outcomes.

AB - This multicountry prospective study investigated whether persistent systemic inflammation, measured by 8 plasma biomarkers, in HIV-1-infected Africans during suppressive antiretroviral therapy (ART) (viral load <50 copies/mL), was associated with CD4+ T-cell recovery and viral rebound (>1000 copies/mL) during long-term treatment. On-ART sCD14 and C-reactive protein concentrations were inversely associated with subsequent CD4+ T-cell counts. Risk of viral rebound was increased for participants with higher on-ART CXCL10 concentrations and reduced for those with a greater sCD163 decline during the first year of ART. Persistent systemic inflammation predicted CD4+ T-cell recovery and viral rebound, warranting further mechanistic research in relation to clinical outcomes.

KW - HIV-1

KW - antiretroviral therapy

KW - biomarkers

KW - cytokines

KW - immune activation

KW - inflammation

KW - sub-Saharan Africa

UR - https://www.scopus.com/pages/publications/85116957794

U2 - 10.1093/infdis/jiaa787

DO - 10.1093/infdis/jiaa787

M3 - Article

C2 - 33373447

SN - 0022-1899

VL - 224

SP - 673

EP - 678

JO - Journal of infectious diseases

JF - Journal of infectious diseases

IS - 4

ER -

Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy

Abstract

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Keywords

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