Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain

Lucy Zhao; Allen Tannenbaum; Erik N T P Bakker; Helene Benveniste

doi:10.1152/physiol.00015.2022

Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain

Lucy Zhao
, Allen Tannenbaum
, Erik N T P Bakker
, Helene Benveniste

the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06519, and Departments of Internal Medicine and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520.
Stony Brook University

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics addressed include the biophysical characteristics of fluid and solute transport in the central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal fluid movement for brain waste clearance. We also discuss the current understanding of mechanisms underlying increased waste clearance during sleep.

Original language	English
Pages (from-to)	0
Number of pages	1
Journal	Physiology (Bethesda, Md.)
Volume	37
Issue number	6
DOIs	https://doi.org/10.1152/physiol.00015.2022
Publication status	Published - 1 Nov 2022

Keywords

brain
cerebrospinal fluid
glymphatic
solute transport
waste clearance

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Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain

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Keywords

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