Pharmacometric validation and optimization of antibiotic dosing in neonates with perinatal asphyxia and premature neonates

M.A.A. van der Veer

Pharmacometric validation and optimization of antibiotic dosing in neonates with perinatal asphyxia and premature neonates

M.A.A. van der Veer

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

Neonatal sepsis remains a clinical challenge for neonates of all gestational ages, necessitating safe and effective antibiotic dosing strategies. However, dosing optimization is especially complicated in neonates presenting with altered pharmacokinetics (PK), such as neonates with perinatal asphyxia or extreme prematurity. This thesis explores antibiotic PK in these vulnerable

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Amsterdam
Supervisors/Advisors	Mathot, Ron, Supervisor van Kaam, Anton, Supervisor Bijleveld, Yuma, Co-supervisor de Haan, Timo, Supervisor
Award date	28 Mar 2025
Publication status	Published - 2025

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https://hdl.handle.net/11245.1/b53d9527-523b-4592-8f05-9f5a4928a0b5

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title = "Pharmacometric validation and optimization of antibiotic dosing in neonates with perinatal asphyxia and premature neonates",

abstract = "Neonatal sepsis remains a clinical challenge for neonates of all gestational ages, necessitating safe and effective antibiotic dosing strategies. However, dosing optimization is especially complicated in neonates presenting with altered pharmacokinetics (PK), such as neonates with perinatal asphyxia or extreme prematurity. This thesis explores antibiotic PK in these vulnerable",

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PY - 2025

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AB - Neonatal sepsis remains a clinical challenge for neonates of all gestational ages, necessitating safe and effective antibiotic dosing strategies. However, dosing optimization is especially complicated in neonates presenting with altered pharmacokinetics (PK), such as neonates with perinatal asphyxia or extreme prematurity. This thesis explores antibiotic PK in these vulnerable

M3 - Phd-Thesis - Research and graduation internal

ER -

Pharmacometric validation and optimization of antibiotic dosing in neonates with perinatal asphyxia and premature neonates

Abstract

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