Pharmacokinetic modeling of a novel hypoxia PET tracer [(18)F]HX4 in patients with non-small cell lung cancer

E E Verwer; C M L Zegers; W van Elmpt; R Wierts; A D Windhorst; F M Mottaghy; P Lambin; R Boellaard

doi:10.1186/s40658-016-0167-y

Pharmacokinetic modeling of a novel hypoxia PET tracer [(18)F]HX4 in patients with non-small cell lung cancer

E E Verwer
, C M L Zegers
, W van Elmpt
, R Wierts
, A D Windhorst
, F M Mottaghy
, P Lambin
, R Boellaard

Harvard Medical School
Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
Department of Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
University Medical Center Groningen

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: [(18)F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [(18)F]HX4 kinetics and assesses the performance of simplified methods for quantification of [(18)F]HX4 uptake. To this end, eight patients with non-small cell lung cancer received dynamic PET scans at three different time points (0, 120, and 240 min) after injection of 426 ± 72 MBq [(18)F]HX4, each lasting 30 min. Several compartment models were fitted to time activity curves (TAC) derived from various areas within tumor tissue using image-derived input functions.

RESULTS: Best fits were obtained using the reversible two-tissue compartment model with blood volume parameter (2T4k+VB). Simplified measures correlated well with VT estimates (tumor-to-blood ratio (TBr) R (2) = 0.96, tumor-to-muscle ratio R (2) = 0.94, standardized uptake value R (2) = 0.89).

CONCLUSIONS: [(18)F]HX4 shows reversible kinetics in tumor tissue: 2T4k+VB. TBr based on static imaging at 2 or 4 h can be used for quantification of [(18)F]HX4 uptake.

Original language	English
Article number	30
Journal	EJNMMI physics
Volume	3
Issue number	1
DOIs	https://doi.org/10.1186/s40658-016-0167-y
Publication status	Published - Dec 2016

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Pharmacokinetic-modeling-of-a-novel-hypoxia-pet-tracer-18fhx4-in-patients-with-non-small-cell-lung-cancer.pdfFinal published version, 613 KBLicence: Taverne

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title = "Pharmacokinetic modeling of a novel hypoxia PET tracer [(18)F]HX4 in patients with non-small cell lung cancer",

abstract = "BACKGROUND: [(18)F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [(18)F]HX4 kinetics and assesses the performance of simplified methods for quantification of [(18)F]HX4 uptake. To this end, eight patients with non-small cell lung cancer received dynamic PET scans at three different time points (0, 120, and 240 min) after injection of 426 ± 72 MBq [(18)F]HX4, each lasting 30 min. Several compartment models were fitted to time activity curves (TAC) derived from various areas within tumor tissue using image-derived input functions.RESULTS: Best fits were obtained using the reversible two-tissue compartment model with blood volume parameter (2T4k+VB). Simplified measures correlated well with VT estimates (tumor-to-blood ratio (TBr) R (2) = 0.96, tumor-to-muscle ratio R (2) = 0.94, standardized uptake value R (2) = 0.89).CONCLUSIONS: [(18)F]HX4 shows reversible kinetics in tumor tissue: 2T4k+VB. TBr based on static imaging at 2 or 4 h can be used for quantification of [(18)F]HX4 uptake.",

author = "Verwer, \{E E\} and Zegers, \{C M L\} and \{van Elmpt\}, W and R Wierts and Windhorst, \{A D\} and Mottaghy, \{F M\} and P Lambin and R Boellaard",

year = "2016",

month = dec,

doi = "10.1186/s40658-016-0167-y",

language = "English",

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T1 - Pharmacokinetic modeling of a novel hypoxia PET tracer [(18)F]HX4 in patients with non-small cell lung cancer

AU - Verwer, E E

AU - Zegers, C M L

AU - van Elmpt, W

AU - Wierts, R

AU - Windhorst, A D

AU - Mottaghy, F M

AU - Lambin, P

AU - Boellaard, R

PY - 2016/12

Y1 - 2016/12

N2 - BACKGROUND: [(18)F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [(18)F]HX4 kinetics and assesses the performance of simplified methods for quantification of [(18)F]HX4 uptake. To this end, eight patients with non-small cell lung cancer received dynamic PET scans at three different time points (0, 120, and 240 min) after injection of 426 ± 72 MBq [(18)F]HX4, each lasting 30 min. Several compartment models were fitted to time activity curves (TAC) derived from various areas within tumor tissue using image-derived input functions.RESULTS: Best fits were obtained using the reversible two-tissue compartment model with blood volume parameter (2T4k+VB). Simplified measures correlated well with VT estimates (tumor-to-blood ratio (TBr) R (2) = 0.96, tumor-to-muscle ratio R (2) = 0.94, standardized uptake value R (2) = 0.89).CONCLUSIONS: [(18)F]HX4 shows reversible kinetics in tumor tissue: 2T4k+VB. TBr based on static imaging at 2 or 4 h can be used for quantification of [(18)F]HX4 uptake.

AB - BACKGROUND: [(18)F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [(18)F]HX4 kinetics and assesses the performance of simplified methods for quantification of [(18)F]HX4 uptake. To this end, eight patients with non-small cell lung cancer received dynamic PET scans at three different time points (0, 120, and 240 min) after injection of 426 ± 72 MBq [(18)F]HX4, each lasting 30 min. Several compartment models were fitted to time activity curves (TAC) derived from various areas within tumor tissue using image-derived input functions.RESULTS: Best fits were obtained using the reversible two-tissue compartment model with blood volume parameter (2T4k+VB). Simplified measures correlated well with VT estimates (tumor-to-blood ratio (TBr) R (2) = 0.96, tumor-to-muscle ratio R (2) = 0.94, standardized uptake value R (2) = 0.89).CONCLUSIONS: [(18)F]HX4 shows reversible kinetics in tumor tissue: 2T4k+VB. TBr based on static imaging at 2 or 4 h can be used for quantification of [(18)F]HX4 uptake.

U2 - 10.1186/s40658-016-0167-y

DO - 10.1186/s40658-016-0167-y

M3 - Article

SN - 2197-7364

VL - 3

JO - EJNMMI physics

JF - EJNMMI physics

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M1 - 30

ER -

Pharmacokinetic modeling of a novel hypoxia PET tracer [(18)F]HX4 in patients with non-small cell lung cancer

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