TY - JOUR
T1 - Performance of Molecular Culture ID in diagnosis of bacterial pericarditis
AU - Bos, Martine P.
AU - Sánchez, Maria Miguélez
AU - Remijas, Lauren
AU - van Houdt, Robin
AU - Peters, Edgar J. G.
AU - Budding, Andries E.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.
PY - 2025/7
Y1 - 2025/7
N2 - Bacterial pericarditis is a serious condition for which diagnosis relies on culture of the pericardial fluid. Culture often remains negative in cases of fastidious organisms or prior antibiotic treatment. To alleviate this issue, we developed Molecular Culture ID (MC-ID), a PCR-based pan-bacterial assay, approved according to the European In Vitro Diagnostic Regulation (IVDR), that identifies bacteria to the species level. Here, we evaluate the diagnostic accuracy of this test on a uniquely large sample set of 42 pericardial effusions. MC-ID identified 11 positive samples whereas culture detected only 7, demonstrating the ability of MC-ID to diagnose bacterial pericarditis.
AB - Bacterial pericarditis is a serious condition for which diagnosis relies on culture of the pericardial fluid. Culture often remains negative in cases of fastidious organisms or prior antibiotic treatment. To alleviate this issue, we developed Molecular Culture ID (MC-ID), a PCR-based pan-bacterial assay, approved according to the European In Vitro Diagnostic Regulation (IVDR), that identifies bacteria to the species level. Here, we evaluate the diagnostic accuracy of this test on a uniquely large sample set of 42 pericardial effusions. MC-ID identified 11 positive samples whereas culture detected only 7, demonstrating the ability of MC-ID to diagnose bacterial pericarditis.
UR - https://www.scopus.com/pages/publications/105002617106
U2 - 10.1007/s10096-025-05125-5
DO - 10.1007/s10096-025-05125-5
M3 - Article
C2 - 40232577
SN - 0934-9723
VL - 44
SP - 1735
EP - 1738
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 7
ER -