PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

Xiuxiang Tan; Jan Bednarsch; Mika Rosin; Simone Appinger; Dong Liu; Georg Wiltberger; Juan Garcia Vallejo; Sven Arke Lang; Zoltan Czigany; Shiva Boroojerdi; Nadine T. Gaisa; Peter Boor; Roman David Bülow; Judith de Vos-Geelen; Liselot Valkenburg-van Iersel; Marian C. Clahsen-van Groningen; Evelien J. M. de Jong; Bas Groot Koerkamp; Michail Doukas; Flavio G. Rocha; Tom Luedde; Uwe Klinge; Shivan Sivakumar; Ulf Peter Neumann; Lara Rosaline Heij

doi:10.3390/cancers14092190

PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

Xiuxiang Tan
, Jan Bednarsch
, Mika Rosin
, Simone Appinger
, Dong Liu
, Georg Wiltberger
, Juan Garcia Vallejo
, Sven Arke Lang
, Zoltan Czigany
, Shiva Boroojerdi
, Nadine T. Gaisa
, Peter Boor
, Roman David Bülow
, Judith de Vos-Geelen
, Liselot Valkenburg-van Iersel
, Marian C. Clahsen-van Groningen
, Evelien J. M. de Jong
, Bas Groot Koerkamp
, Michail Doukas
, Flavio G. Rocha

Tom Luedde, Uwe Klinge, Shivan Sivakumar, Ulf Peter Neumann, Lara Rosaline Heij^*

^*Corresponding author for this work

European Vascular Center Aachen-Maastricht
Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research Institute GROW, University of Maastricht, Maastricht, The Netherlands;
Erasmus University Rotterdam
Erasmus MC Cancer Institute
Oregon Health and Science University
Heinrich Heine University Düsseldorf
University of Oxford
University of Limburg

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small nerve fibers (high vs low NFD). NFD is different than perineural invasion (PNI),.

Original language	English
Article number	2190
Journal	Cancers
Volume	14
Issue number	9
DOIs	https://doi.org/10.3390/cancers14092190
Publication status	Published - 1 May 2022

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10.3390/cancers14092190

Pd-1-t-cells-correlate-with-nerve-fiber-density-as-a-prognostic-biomarker-in-patients-with-resected-perihilar-cholangio.pdfFinal published version, 3.69 MBLicence: CC BY

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Tan, X., Bednarsch, J., Rosin, M., Appinger, S., Liu, D., Wiltberger, G., Garcia Vallejo, J., Lang, S. A., Czigany, Z., Boroojerdi, S., Gaisa, N. T., Boor, P., Bülow, R. D., de Vos-Geelen, J., Valkenburg-van Iersel, L., Clahsen-van Groningen, M. C., de Jong, E. J. M., Koerkamp, B. G., Doukas, M., ... Heij, L. R. (2022). PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma. Cancers, 14(9), Article 2190. https://doi.org/10.3390/cancers14092190

@article{cb3b04e3ee5b49bb9ff4dccc5d0e66db,

title = "PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma",

abstract = "Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small nerve fibers (high vs low NFD). NFD is different than perineural invasion (PNI),.",

author = "Xiuxiang Tan and Jan Bednarsch and Mika Rosin and Simone Appinger and Dong Liu and Georg Wiltberger and \{Garcia Vallejo\}, Juan and Lang, \{Sven Arke\} and Zoltan Czigany and Shiva Boroojerdi and Gaisa, \{Nadine T.\} and Peter Boor and B{\"u}low, \{Roman David\} and \{de Vos-Geelen\}, Judith and \{Valkenburg-van Iersel\}, Liselot and \{Clahsen-van Groningen\}, \{Marian C.\} and \{de Jong\}, \{Evelien J. M.\} and Koerkamp, \{Bas Groot\} and Michail Doukas and Rocha, \{Flavio G.\} and Tom Luedde and Uwe Klinge and Shivan Sivakumar and Neumann, \{Ulf Peter\} and Heij, \{Lara Rosaline\}",

note = "Funding Information: Funding: This study was supported by the China Scholarship Council, which provided a PhD-fellowship grant to Xiuxiang Tan (number 201806210074). Publisher Copyright: 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

day = "1",

doi = "10.3390/cancers14092190",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

}

Tan, X, Bednarsch, J, Rosin, M, Appinger, S, Liu, D, Wiltberger, G, Garcia Vallejo, J, Lang, SA, Czigany, Z, Boroojerdi, S, Gaisa, NT, Boor, P, Bülow, RD, de Vos-Geelen, J, Valkenburg-van Iersel, L, Clahsen-van Groningen, MC, de Jong, EJM, Koerkamp, BG, Doukas, M, Rocha, FG, Luedde, T, Klinge, U, Sivakumar, S, Neumann, UP & Heij, LR 2022, 'PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma', Cancers, vol. 14, no. 9, 2190. https://doi.org/10.3390/cancers14092190

TY - JOUR

T1 - PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

AU - Tan, Xiuxiang

AU - Bednarsch, Jan

AU - Rosin, Mika

AU - Appinger, Simone

AU - Liu, Dong

AU - Wiltberger, Georg

AU - Garcia Vallejo, Juan

AU - Lang, Sven Arke

AU - Czigany, Zoltan

AU - Boroojerdi, Shiva

AU - Gaisa, Nadine T.

AU - Boor, Peter

AU - Bülow, Roman David

AU - de Vos-Geelen, Judith

AU - Valkenburg-van Iersel, Liselot

AU - Clahsen-van Groningen, Marian C.

AU - de Jong, Evelien J. M.

AU - Koerkamp, Bas Groot

AU - Doukas, Michail

AU - Rocha, Flavio G.

AU - Luedde, Tom

AU - Klinge, Uwe

AU - Sivakumar, Shivan

AU - Neumann, Ulf Peter

AU - Heij, Lara Rosaline

N1 - Funding Information: Funding: This study was supported by the China Scholarship Council, which provided a PhD-fellowship grant to Xiuxiang Tan (number 201806210074). Publisher Copyright: 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small nerve fibers (high vs low NFD). NFD is different than perineural invasion (PNI),.

AB - Background and Aims: Perihilar cholangiocarcinoma (pCCA) is a hepatobiliary malignancy, with a dismal prognosis. Nerve fiber density (NFD)—a novel prognostic biomarker—describes the density of small nerve fibers without cancer invasion and is categorized into high numbers and low numbers of small nerve fibers (high vs low NFD). NFD is different than perineural invasion (PNI),.

UR - https://www.scopus.com/pages/publications/85129092670

U2 - 10.3390/cancers14092190

DO - 10.3390/cancers14092190

M3 - Article

C2 - 35565318

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 9

M1 - 2190

ER -

PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

Abstract

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