TY - JOUR
T1 - Pathophysiology of gastroesophageal reflux disease
AU - Boeckxstaens, Guy E.
AU - Rohof, Wout O.
PY - 2014
Y1 - 2014
N2 - Gastroesophageal reflux disease (GERD) is one of the most common digestive diseases in the Western world, with typical symptoms, such as heartburn, regurgitation, or retrosternal pain, reported by 15% to 20% of the general population. The pathophysiology of GERD is multifactorial. Our understanding of these factors has significantly improved in recent years, with increased understanding of the acid pocket and hiatal hernia and how these factors interact. Although our insight has significantly increased over the past years, more studies are required to better understand symptom generation in GERD, especially in patients with therapy-resistant symptoms
AB - Gastroesophageal reflux disease (GERD) is one of the most common digestive diseases in the Western world, with typical symptoms, such as heartburn, regurgitation, or retrosternal pain, reported by 15% to 20% of the general population. The pathophysiology of GERD is multifactorial. Our understanding of these factors has significantly improved in recent years, with increased understanding of the acid pocket and hiatal hernia and how these factors interact. Although our insight has significantly increased over the past years, more studies are required to better understand symptom generation in GERD, especially in patients with therapy-resistant symptoms
U2 - 10.1016/j.gtc.2013.11.001
DO - 10.1016/j.gtc.2013.11.001
M3 - Article
C2 - 24503356
SN - 0889-8553
VL - 43
SP - 15
EP - 25
JO - Gastroenterology clinics of North America
JF - Gastroenterology clinics of North America
IS - 1
ER -