Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis

Chiara C. M. M. Lap; Maria L. Brizot; Lourens R. Pistorius; William L. M. Kramer; Ivo B. Teeuwen; Marinus J. Eijkemans; Hens A. A. Brouwers; Eva Pajkrt; Anton H. van Kaam; Phebe N. Adama van Scheltema; Alex J. Eggink; Arno F. van Heijst; Monique C. Haak; Mirjam M. van Weissenbruch; Christien Sleeboom; Christine Willekes; Mark A. van der Hoeven; Ernst L. van Heurn; Catherina M. Bilardo; Peter H. Dijk; Robertine van Baren; Rossana P. V. Francisco; Ana C. A. Tannuri; Gerard H. A. Visser; Gwendolyn T. R. Manten

doi:10.1016/j.earlhumdev.2016.10.002

Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis

Chiara C. M. M. Lap
, Maria L. Brizot
, Lourens R. Pistorius
, William L. M. Kramer
, Ivo B. Teeuwen
, Marinus J. Eijkemans
, Hens A. A. Brouwers
, Eva Pajkrt
, Anton H. van Kaam
, Phebe N. Adama van Scheltema
, Alex J. Eggink
, Arno F. van Heijst
, Monique C. Haak
, Mirjam M. van Weissenbruch
, Christien Sleeboom
, Christine Willekes
, Mark A. van der Hoeven
, Ernst L. van Heurn
, Catherina M. Bilardo
, Peter H. Dijk

Robertine van Baren, Rossana P. V. Francisco, Ana C. A. Tannuri, Gerard H. A. Visser, Gwendolyn T. R. Manten

University Medical Center Utrecht, Division Woman and Baby, Department of Obstetrics, Utrecht, The Netherlands.. Electronic address: [email protected].
Department of Obstetrics and Gynaecology, Hospital das Clínicas, São Paulo University Medical School, São Paulo, SP, Brazil.. Electronic address: [email protected].
University Medical Center Utrecht, Division Woman and Baby, Department of Obstetrics, Utrecht, The Netherlands.; University of Stellenbosch, Department of Obstetrics and Gynaecology, Stellenbosch, South Africa.. Electronic address: [email protected].
University Medical Center Utrecht, Department of Paediatric Surgery, Utrecht, The Netherlands.. Electronic address: [email protected].
Maastricht University Medical Center+, Department of Anesthesiology, Maastricht, The Netherlands.. Electronic address: [email protected].
University Medical Center Utrecht, Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands.. Electronic address: [email protected].
University Medical Center Utrecht, Division Woman and Baby, Department of Neonatology, Utrecht, The Netherlands.. Electronic address: [email protected].
Academic Medical Center Amsterdam, Department of Obstetrics and Gynaecology, Amsterdam, The Netherlands.. Electronic address: [email protected].
Emma Children's Hospital, Academic Medical Center Amsterdam, Department of Neonatology, Amsterdam, The Netherlands.. Electronic address: [email protected].
Leiden University Medical Center, Department of Obstetrics and Gynaecology, Leiden, The Netherlands.. Electronic address: [email protected].
Radboud University Medical Center, Department of Obstetrics and Gynaecology, Nijmegen, The Netherlands.; Erasmus MC University Medical Centre Rotterdam, Department of Obstetrics and Gynaecology, Rotterdam, The Netherlands.. Electronic address: [email protected].
Radboud University Medical Center, Department of Neonatology, Nijmegen, The Netherlands.. Electronic address: [email protected].
Pediatric Surgical Center of Amsterdam, Emma Children's Hospital University Medical Center and VU Medical Center, Amsterdam, the Netherlands.. Electronic address: [email protected].
Maastricht University Medical Center+, Department of Obstetrics and Gynaecology, Maastricht, The Netherlands.. Electronic address: [email protected].
Maastricht University Medical Center+, Department of Neonatology, Maastricht, The Netherlands.. Electronic address: [email protected].
University Medical Center Groningen, Department of Obstetrics and Gynaecology, Groningen, The Netherlands.. Electronic address: [email protected].
University Medical Center Groningen, University of Groningen, Department of Neonatology Beatrix Children's Hospital, Groningen, The Netherlands.. Electronic address: [email protected].
University Medical Center Groningen, University of Groningen, Department of Paediatric Surgery, Groningen, The Netherlands.. Electronic address: [email protected].
Department of Obstetrics and Gynaecology, Hospital das Clínicas, São Paulo University Medical School, São Paulo, SP, Brazil.. Electronic address: [email protected].
Department of Pediatric, Pediatric Surgery Division, São Paulo University Medical School, São Paulo, SP, Brazil.
University Medical Center Utrecht, Division Woman and Baby, Department of Obstetrics, Utrecht, The Netherlands.. Electronic address: [email protected].
University Medical Center Utrecht, Division Woman and Baby, Department of Obstetrics, Utrecht, The Netherlands.. Electronic address: [email protected].

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

To determine outcome of children born with isolated gastroschisis (no extra-gastrointestinal congenital abnormalities). International cohort study and meta-analysis. time to full enteral feeding (TFEF); secondary outcomes: Duration of mechanical ventilation, length of stay (LOS), mortality and differences in outcome between simple and complex gastroschisis (complex; born with bowel atresia, volvulus, perforation or necrosis). To compare the cohort study results with literature three databases were searched. Studies were eligible for inclusion if cases were born in developed countries with isolated gastroschisis after 1990, number of cases >20 and TFEF was reported. The cohort study included 204 liveborn cases of isolated gastroschisis. The TFEF, median duration of ventilation and LOS was, 26days (range 6-515), 2days (range 0-90) and 33days (range 11-515), respectively. Overall mortality was 10.8%. TFEF and LOS were significantly longer (P <0.0001) and mortality was fourfold higher in the complex group. Seventeen studies, amongst the current study, were included for further meta-analysis comprising a total of 1652 patients. Mean TFEF was 35.3±4.4days, length of ventilation was 5.5±2.0days, LOS was 46.4±5.2days and mortality risk was 0.06 [0.04-0.07 95%CI]. Outcome of simple and complex gastroschisis was described in five studies. TFEF, ventilation time, LOS were significant longer and mortality rate was 3.64 [1.95-6.83 95%CI] times higher in complex cases. These results give a good indication of the expected TFEF, ventilation time and LOS and mortality risk in children born with isolated gastroschisis, although ranges remain wide. This study shows the importance of dividing gastroschisis into simple and complex for the prediction of outcome

Original language	English
Pages (from-to)	209-218
Number of pages	10
Journal	Early human development
Volume	103
DOIs	https://doi.org/10.1016/j.earlhumdev.2016.10.002
Publication status	Published - Dec 2016

Keywords

Journal Article

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10.1016/j.earlhumdev.2016.10.002

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Lap, C. C. M. M., Brizot, M. L., Pistorius, L. R., Kramer, W. L. M., Teeuwen, I. B., Eijkemans, M. J., Brouwers, H. A. A., Pajkrt, E., van Kaam, A. H., Adama van Scheltema, P. N., Eggink, A. J., van Heijst, A. F., Haak, M. C., van Weissenbruch, M. M., Sleeboom, C., Willekes, C., van der Hoeven, M. A., van Heurn, E. L., Bilardo, C. M., ... Manten, G. T. R. (2016). Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis. Early human development, 103, 209-218. https://doi.org/10.1016/j.earlhumdev.2016.10.002

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title = "Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis",

abstract = "To determine outcome of children born with isolated gastroschisis (no extra-gastrointestinal congenital abnormalities). International cohort study and meta-analysis. time to full enteral feeding (TFEF); secondary outcomes: Duration of mechanical ventilation, length of stay (LOS), mortality and differences in outcome between simple and complex gastroschisis (complex; born with bowel atresia, volvulus, perforation or necrosis). To compare the cohort study results with literature three databases were searched. Studies were eligible for inclusion if cases were born in developed countries with isolated gastroschisis after 1990, number of cases >20 and TFEF was reported. The cohort study included 204 liveborn cases of isolated gastroschisis. The TFEF, median duration of ventilation and LOS was, 26days (range 6-515), 2days (range 0-90) and 33days (range 11-515), respectively. Overall mortality was 10.8\%. TFEF and LOS were significantly longer (P <0.0001) and mortality was fourfold higher in the complex group. Seventeen studies, amongst the current study, were included for further meta-analysis comprising a total of 1652 patients. Mean TFEF was 35.3±4.4days, length of ventilation was 5.5±2.0days, LOS was 46.4±5.2days and mortality risk was 0.06 [0.04-0.07 95\%CI]. Outcome of simple and complex gastroschisis was described in five studies. TFEF, ventilation time, LOS were significant longer and mortality rate was 3.64 [1.95-6.83 95\%CI] times higher in complex cases. These results give a good indication of the expected TFEF, ventilation time and LOS and mortality risk in children born with isolated gastroschisis, although ranges remain wide. This study shows the importance of dividing gastroschisis into simple and complex for the prediction of outcome",

keywords = "Journal Article",

author = "Lap, \{Chiara C. M. M.\} and Brizot, \{Maria L.\} and Pistorius, \{Lourens R.\} and Kramer, \{William L. M.\} and Teeuwen, \{Ivo B.\} and Eijkemans, \{Marinus J.\} and Brouwers, \{Hens A. A.\} and Eva Pajkrt and \{van Kaam\}, \{Anton H.\} and \{Adama van Scheltema\}, \{Phebe N.\} and Eggink, \{Alex J.\} and \{van Heijst\}, \{Arno F.\} and Haak, \{Monique C.\} and \{van Weissenbruch\}, \{Mirjam M.\} and Christien Sleeboom and Christine Willekes and \{van der Hoeven\}, \{Mark A.\} and \{van Heurn\}, \{Ernst L.\} and Bilardo, \{Catherina M.\} and Dijk, \{Peter H.\} and \{van Baren\}, Robertine and Francisco, \{Rossana P. V.\} and Tannuri, \{Ana C. A.\} and Visser, \{Gerard H. A.\} and Manten, \{Gwendolyn T. R.\}",

year = "2016",

month = dec,

doi = "10.1016/j.earlhumdev.2016.10.002",

language = "English",

volume = "103",

pages = "209--218",

journal = "Early human development",

issn = "0378-3782",

publisher = "Elsevier Ireland Ltd",

}

Lap, CCMM, Brizot, ML, Pistorius, LR, Kramer, WLM, Teeuwen, IB, Eijkemans, MJ, Brouwers, HAA, Pajkrt, E , van Kaam, AH, Adama van Scheltema, PN, Eggink, AJ, van Heijst, AF, Haak, MC, van Weissenbruch, MM, Sleeboom, C, Willekes, C, van der Hoeven, MA, van Heurn, EL, Bilardo, CM, Dijk, PH, van Baren, R, Francisco, RPV, Tannuri, ACA, Visser, GHA & Manten, GTR 2016, 'Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis', Early human development, vol. 103, pp. 209-218. https://doi.org/10.1016/j.earlhumdev.2016.10.002

TY - JOUR

T1 - Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis

AU - Lap, Chiara C. M. M.

AU - Brizot, Maria L.

AU - Pistorius, Lourens R.

AU - Kramer, William L. M.

AU - Teeuwen, Ivo B.

AU - Eijkemans, Marinus J.

AU - Brouwers, Hens A. A.

AU - Pajkrt, Eva

AU - van Kaam, Anton H.

AU - Adama van Scheltema, Phebe N.

AU - Eggink, Alex J.

AU - van Heijst, Arno F.

AU - Haak, Monique C.

AU - van Weissenbruch, Mirjam M.

AU - Sleeboom, Christien

AU - Willekes, Christine

AU - van der Hoeven, Mark A.

AU - van Heurn, Ernst L.

AU - Bilardo, Catherina M.

AU - Dijk, Peter H.

AU - van Baren, Robertine

AU - Francisco, Rossana P. V.

AU - Tannuri, Ana C. A.

AU - Visser, Gerard H. A.

AU - Manten, Gwendolyn T. R.

PY - 2016/12

Y1 - 2016/12

N2 - To determine outcome of children born with isolated gastroschisis (no extra-gastrointestinal congenital abnormalities). International cohort study and meta-analysis. time to full enteral feeding (TFEF); secondary outcomes: Duration of mechanical ventilation, length of stay (LOS), mortality and differences in outcome between simple and complex gastroschisis (complex; born with bowel atresia, volvulus, perforation or necrosis). To compare the cohort study results with literature three databases were searched. Studies were eligible for inclusion if cases were born in developed countries with isolated gastroschisis after 1990, number of cases >20 and TFEF was reported. The cohort study included 204 liveborn cases of isolated gastroschisis. The TFEF, median duration of ventilation and LOS was, 26days (range 6-515), 2days (range 0-90) and 33days (range 11-515), respectively. Overall mortality was 10.8%. TFEF and LOS were significantly longer (P <0.0001) and mortality was fourfold higher in the complex group. Seventeen studies, amongst the current study, were included for further meta-analysis comprising a total of 1652 patients. Mean TFEF was 35.3±4.4days, length of ventilation was 5.5±2.0days, LOS was 46.4±5.2days and mortality risk was 0.06 [0.04-0.07 95%CI]. Outcome of simple and complex gastroschisis was described in five studies. TFEF, ventilation time, LOS were significant longer and mortality rate was 3.64 [1.95-6.83 95%CI] times higher in complex cases. These results give a good indication of the expected TFEF, ventilation time and LOS and mortality risk in children born with isolated gastroschisis, although ranges remain wide. This study shows the importance of dividing gastroschisis into simple and complex for the prediction of outcome

AB - To determine outcome of children born with isolated gastroschisis (no extra-gastrointestinal congenital abnormalities). International cohort study and meta-analysis. time to full enteral feeding (TFEF); secondary outcomes: Duration of mechanical ventilation, length of stay (LOS), mortality and differences in outcome between simple and complex gastroschisis (complex; born with bowel atresia, volvulus, perforation or necrosis). To compare the cohort study results with literature three databases were searched. Studies were eligible for inclusion if cases were born in developed countries with isolated gastroschisis after 1990, number of cases >20 and TFEF was reported. The cohort study included 204 liveborn cases of isolated gastroschisis. The TFEF, median duration of ventilation and LOS was, 26days (range 6-515), 2days (range 0-90) and 33days (range 11-515), respectively. Overall mortality was 10.8%. TFEF and LOS were significantly longer (P <0.0001) and mortality was fourfold higher in the complex group. Seventeen studies, amongst the current study, were included for further meta-analysis comprising a total of 1652 patients. Mean TFEF was 35.3±4.4days, length of ventilation was 5.5±2.0days, LOS was 46.4±5.2days and mortality risk was 0.06 [0.04-0.07 95%CI]. Outcome of simple and complex gastroschisis was described in five studies. TFEF, ventilation time, LOS were significant longer and mortality rate was 3.64 [1.95-6.83 95%CI] times higher in complex cases. These results give a good indication of the expected TFEF, ventilation time and LOS and mortality risk in children born with isolated gastroschisis, although ranges remain wide. This study shows the importance of dividing gastroschisis into simple and complex for the prediction of outcome

KW - Journal Article

U2 - 10.1016/j.earlhumdev.2016.10.002

DO - 10.1016/j.earlhumdev.2016.10.002

M3 - Review article

C2 - 27825040

SN - 0378-3782

VL - 103

SP - 209

EP - 218

JO - Early human development

JF - Early human development

ER -

Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis

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Keywords

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