TY - JOUR
T1 - Outcome of Cataract Surgery in Patients With Retinitis Pigmentosa
AU - Nguyen, Xuan-Thanh-An
AU - Thiadens, Alberta A. H. J.
AU - Fiocco, Marta
AU - Tan, Weijen
AU - McKibbin, Martin
AU - Klaver, Caroline C. W.
AU - Meester-Smoor, Magda A.
AU - van Cauwenbergh, Caroline
AU - Strubbe, Ine
AU - Vergaro, Andrea
AU - Pott, Jan-Willem R.
AU - Hoyng, Carel B.
AU - Leroy, Bart P.
AU - Zemaitiene, Reda
AU - Khan, Kamron N.
AU - Boon, Camiel J. F.
N1 - Funding Information:
Acknowledgements: This study was performed as part of a collaboration within the European Reference Network for Rare Eye Diseases (ERN-EYE). ERN-EYE is founded by the Health Program of the European Union under the Framework Partnership Agreement #739543 “ERN-EYE” and cofounded by the Hôpitaux Universitaires de Strasbourg.
Funding Information:
Funding/Support: for author Vergaro A Genetic analysis was supported by grant EJP RD Solve-RET (Reference Number: EJPRD19-234) from The Ministry of Education, Youth and Sports, Czech Republic (to A.V.).
Funding Information:
ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF INTEREST and none were reported. Funding/Support: for author Vergaro A Genetic analysis was supported by grant EJP RD Solve-RET (Reference Number: EJPRD19-234) from The Ministry of Education, Youth and Sports, Czech Republic (to A.V.). Financial Disclosures: The authors indicate no financial support or conflicts of interest. All authors attest that they meet the current ICMJE criteria for authorship. Acknowledgements: This study was performed as part of a collaboration within the European Reference Network for Rare Eye Diseases (ERN-EYE). ERN-EYE is founded by the Health Program of the European Union under the Framework Partnership Agreement #739543 “ERN-EYE” and cofounded by the Hôpitaux Universitaires de Strasbourg.
Publisher Copyright:
© 2022 The Author(s)
PY - 2023/2/1
Y1 - 2023/2/1
N2 - PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 225 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (−0.22 logMAR; 95% CI = −0.31 to −0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (−0.24 logMAR; 95% CI = −0.32 to −0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.
AB - PURPOSE: To assess the visual outcome of cataract surgery in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, noncomparative clinical study. METHODS: Preoperative, intraoperative, and postoperative data of patients with RP who were undergoing cataract surgery were collected from several expertise centers across Europe. RESULTS: In total, 295 eyes of 225 patients were included in the study. The mean age at surgery of the first eye was 56.1 ± 17.9 years. Following surgery, best-corrected visual acuity (BCVA) improved significantly from 1.03 to 0.81 logMAR (ie, 20/214 to 20/129 Snellen) in the first treated eye (−0.22 logMAR; 95% CI = −0.31 to −0.13; P < .001) and from 0.80 to 0.56 logMAR (ie, 20/126 to 20/73 Snellen) in the second treated eye (−0.24 logMAR; 95% CI = −0.32 to −0.15; P < .001). Marked BCVA improvements (postoperative change in BCVA of ≥0.3 logMAR) were observed in 87 of 226 patients (39%). Greater odds for marked visual improvements were observed in patients with moderate visual impairment or worse. The most common complications were zonular dialysis (n = 15; 5%) and (exacerbation of) cystoid macular edema (n = 14; 5%), respectively. Postoperative posterior capsular opacifications were present in 111 of 295 eyes (38%). CONCLUSION: Significant improvements in BCVA are observed in most patients with RP following cataract surgery. Baseline BCVA is a predictor of visual outcome. Preoperative evaluation should include the assessment of potential zonular insufficiency and the presence of CME, as they are relatively common and may increase the risk of complications.
UR - https://www.scopus.com/pages/publications/85142309973
U2 - 10.1016/j.ajo.2022.10.001
DO - 10.1016/j.ajo.2022.10.001
M3 - Article
C2 - 36252678
SN - 0002-9394
VL - 246
SP - 1
EP - 9
JO - American journal of ophthalmology
JF - American journal of ophthalmology
ER -