Origin of ganglioside complex antibodies in Guillain-Barré syndrome

Mark L. Kuijf; Peggy C. R. Godschalk; Michel Gilbert; Hubert P. Endtz; Anne P. Tio-Gillen; C. Wim Ang; Pieter A. van Doorn; Bart C. Jacobs

doi:10.1016/j.jneuroim.2007.05.014

Origin of ganglioside complex antibodies in Guillain-Barré syndrome

Mark L. Kuijf
, Peggy C. R. Godschalk
, Michel Gilbert
, Hubert P. Endtz
, Anne P. Tio-Gillen
, C. Wim Ang
, Pieter A. van Doorn
, Bart C. Jacobs

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The origin of antibodies to ganglioside complexes, as new immunotargets for Guillain-Barré syndrome (GBS), is unknown. This was investigated in 21 GBS patients from which Campylobacter jejuni was isolated. Two of these patients had serum IgG to the GM1/GD1a complex and two other patients had IgG to the GQ1b/GD1a complex. These pairs of patients were clinically distinct. These antibodies all cross-reacted to lipo-oligosaccharides (LOS) from the autologous C. jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies

Original language	English
Pages (from-to)	69-73
Journal	Journal of neuroimmunology
Volume	188
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.05.014
Publication status	Published - 2007

Access to Document

10.1016/j.jneuroim.2007.05.014

Cite this

@article{f82fa2d6cc8c47edb0166d689ee7ab61,

title = "Origin of ganglioside complex antibodies in Guillain-Barr{\'e} syndrome",

abstract = "The origin of antibodies to ganglioside complexes, as new immunotargets for Guillain-Barr{\'e} syndrome (GBS), is unknown. This was investigated in 21 GBS patients from which Campylobacter jejuni was isolated. Two of these patients had serum IgG to the GM1/GD1a complex and two other patients had IgG to the GQ1b/GD1a complex. These pairs of patients were clinically distinct. These antibodies all cross-reacted to lipo-oligosaccharides (LOS) from the autologous C. jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies",

author = "Kuijf, \{Mark L.\} and Godschalk, \{Peggy C. R.\} and Michel Gilbert and Endtz, \{Hubert P.\} and Tio-Gillen, \{Anne P.\} and Ang, \{C. Wim\} and \{van Doorn\}, \{Pieter A.\} and Jacobs, \{Bart C.\}",

year = "2007",

doi = "10.1016/j.jneuroim.2007.05.014",

language = "English",

volume = "188",

pages = "69--73",

journal = "Journal of neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Origin of ganglioside complex antibodies in Guillain-Barré syndrome

AU - Kuijf, Mark L.

AU - Godschalk, Peggy C. R.

AU - Gilbert, Michel

AU - Endtz, Hubert P.

AU - Tio-Gillen, Anne P.

AU - Ang, C. Wim

AU - van Doorn, Pieter A.

AU - Jacobs, Bart C.

PY - 2007

Y1 - 2007

N2 - The origin of antibodies to ganglioside complexes, as new immunotargets for Guillain-Barré syndrome (GBS), is unknown. This was investigated in 21 GBS patients from which Campylobacter jejuni was isolated. Two of these patients had serum IgG to the GM1/GD1a complex and two other patients had IgG to the GQ1b/GD1a complex. These pairs of patients were clinically distinct. These antibodies all cross-reacted to lipo-oligosaccharides (LOS) from the autologous C. jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies

AB - The origin of antibodies to ganglioside complexes, as new immunotargets for Guillain-Barré syndrome (GBS), is unknown. This was investigated in 21 GBS patients from which Campylobacter jejuni was isolated. Two of these patients had serum IgG to the GM1/GD1a complex and two other patients had IgG to the GQ1b/GD1a complex. These pairs of patients were clinically distinct. These antibodies all cross-reacted to lipo-oligosaccharides (LOS) from the autologous C. jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies

U2 - 10.1016/j.jneuroim.2007.05.014

DO - 10.1016/j.jneuroim.2007.05.014

M3 - Article

C2 - 17604126

SN - 0165-5728

VL - 188

SP - 69

EP - 73

JO - Journal of neuroimmunology

JF - Journal of neuroimmunology

IS - 1-2

ER -

Origin of ganglioside complex antibodies in Guillain-Barré syndrome

Abstract

Access to Document

Fingerprint

Cite this