OPTIMIZATION OF DIRECT COMPRESSION TABLET FORMULATIONS FOR USE IN TROPICAL COUNTRIES

C. E. Bos; G. K. BOLHUIS; C. F. LERK; J. H. de Boer; C. A. A. DUINEVELD; A. K. Smilde; D. A. Doornbos

doi:10.3109/03639049109048088

OPTIMIZATION OF DIRECT COMPRESSION TABLET FORMULATIONS FOR USE IN TROPICAL COUNTRIES

C. E. Bos
, G. K. BOLHUIS
, C. F. LERK
, J. H. de Boer
, C. A. A. DUINEVELD
, A. K. Smilde
, D. A. Doornbos

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

With the aid of a combined mixture- and factorial- design, 2 standard tablet formulations were selected suitable for use in tropical countries. The formulations were based on native ingredients or ingredients that are available worldwide. The selection of the standard formulations was based on both the initial tablet properties of the formulations one day after preparation as well as the physical stability after storage under tropical conditions. The selected formulations were evaluated by adding model drugs (diazepam, 2 mg per tablet or hydrochlorthiazide, 100 mg per tablet) and measuring tablet properties, not only one day after preparation, but also after storage under tropical conditions. Both selected tablet formulations were suitable standard formulations for tablets prepared by direct compression for use in tropical countries

Original language	English
Pages (from-to)	2477-2496
Journal	Drug development and industrial pharmacy
Volume	17
Issue number	18
DOIs	https://doi.org/10.3109/03639049109048088
Publication status	Published - 1991

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title = "OPTIMIZATION OF DIRECT COMPRESSION TABLET FORMULATIONS FOR USE IN TROPICAL COUNTRIES",

abstract = "With the aid of a combined mixture- and factorial- design, 2 standard tablet formulations were selected suitable for use in tropical countries. The formulations were based on native ingredients or ingredients that are available worldwide. The selection of the standard formulations was based on both the initial tablet properties of the formulations one day after preparation as well as the physical stability after storage under tropical conditions. The selected formulations were evaluated by adding model drugs (diazepam, 2 mg per tablet or hydrochlorthiazide, 100 mg per tablet) and measuring tablet properties, not only one day after preparation, but also after storage under tropical conditions. Both selected tablet formulations were suitable standard formulations for tablets prepared by direct compression for use in tropical countries",

author = "Bos, \{C. E.\} and BOLHUIS, \{G. K.\} and LERK, \{C. F.\} and \{de Boer\}, \{J. H.\} and DUINEVELD, \{C. A. A.\} and Smilde, \{A. K.\} and Doornbos, \{D. A.\}",

year = "1991",

doi = "10.3109/03639049109048088",

language = "English",

volume = "17",

pages = "2477--2496",

journal = "Drug development and industrial pharmacy",

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T1 - OPTIMIZATION OF DIRECT COMPRESSION TABLET FORMULATIONS FOR USE IN TROPICAL COUNTRIES

AU - Bos, C. E.

AU - BOLHUIS, G. K.

AU - LERK, C. F.

AU - de Boer, J. H.

AU - DUINEVELD, C. A. A.

AU - Smilde, A. K.

AU - Doornbos, D. A.

PY - 1991

Y1 - 1991

N2 - With the aid of a combined mixture- and factorial- design, 2 standard tablet formulations were selected suitable for use in tropical countries. The formulations were based on native ingredients or ingredients that are available worldwide. The selection of the standard formulations was based on both the initial tablet properties of the formulations one day after preparation as well as the physical stability after storage under tropical conditions. The selected formulations were evaluated by adding model drugs (diazepam, 2 mg per tablet or hydrochlorthiazide, 100 mg per tablet) and measuring tablet properties, not only one day after preparation, but also after storage under tropical conditions. Both selected tablet formulations were suitable standard formulations for tablets prepared by direct compression for use in tropical countries

AB - With the aid of a combined mixture- and factorial- design, 2 standard tablet formulations were selected suitable for use in tropical countries. The formulations were based on native ingredients or ingredients that are available worldwide. The selection of the standard formulations was based on both the initial tablet properties of the formulations one day after preparation as well as the physical stability after storage under tropical conditions. The selected formulations were evaluated by adding model drugs (diazepam, 2 mg per tablet or hydrochlorthiazide, 100 mg per tablet) and measuring tablet properties, not only one day after preparation, but also after storage under tropical conditions. Both selected tablet formulations were suitable standard formulations for tablets prepared by direct compression for use in tropical countries

U2 - 10.3109/03639049109048088

DO - 10.3109/03639049109048088

M3 - Article

SN - 0363-9045

VL - 17

SP - 2477

EP - 2496

JO - Drug development and industrial pharmacy

JF - Drug development and industrial pharmacy

IS - 18

ER -

OPTIMIZATION OF DIRECT COMPRESSION TABLET FORMULATIONS FOR USE IN TROPICAL COUNTRIES

Abstract

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