Optimising PROTACs against integral membrane proteins

C. Ruffilli

Optimising PROTACs against integral membrane proteins

C. Ruffilli

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

Integral membrane proteins (IMPs) play a critical role in the pathophysiology of a range of diseases. Resistance mechanisms to conventional IMP-targeted therapeutics have driven the need for novel modalities. While PROteolysis TArgeting Chimeras (PROTACs) have shown significant potential for degrading cytosolic proteins, their use in the targeted degradation of IMPs remains

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Amsterdam
Supervisors/Advisors	Zelcer, Noam, Supervisor Moreau, Kevin, Co-supervisor, External person
Award date	27 Jun 2025
Publication status	Published - 2025

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https://hdl.handle.net/11245.1/252c7697-ae37-442e-9d9e-54137c272f7b

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title = "Optimising PROTACs against integral membrane proteins",

abstract = "Integral membrane proteins (IMPs) play a critical role in the pathophysiology of a range of diseases. Resistance mechanisms to conventional IMP-targeted therapeutics have driven the need for novel modalities. While PROteolysis TArgeting Chimeras (PROTACs) have shown significant potential for degrading cytosolic proteins, their use in the targeted degradation of IMPs remains",

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year = "2025",

language = "English",

type = "Phd-Thesis - Research and graduation internal",

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AB - Integral membrane proteins (IMPs) play a critical role in the pathophysiology of a range of diseases. Resistance mechanisms to conventional IMP-targeted therapeutics have driven the need for novel modalities. While PROteolysis TArgeting Chimeras (PROTACs) have shown significant potential for degrading cytosolic proteins, their use in the targeted degradation of IMPs remains

M3 - Phd-Thesis - Research and graduation internal

ER -

Optimising PROTACs against integral membrane proteins

Abstract

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