TY - CHAP
T1 - Opportunities for lipid-based probes in the field of immunology
AU - Koenders, Sebastiaan T.A.
AU - Gagestein, Berend
AU - van der Stelt, Mario
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2018.
PY - 2019
Y1 - 2019
N2 - Lipids perform a wide range of functions inside the cell, ranging from structural building block of membranes and energy storage to cell signaling. The mode of action of many signaling lipids has remained elusive due to their low abundance, high lipophilicity, and inherent instability. Various chemical biology approaches, such as photoaffinity or activity-based protein profiling methods, have been employed to shed light on the biological role of lipids and the lipid–protein interaction profile. In this review, we will summarize the recent developments in the field of chemical probes to study lipid biology, especially in immunology, and indicate potential avenues for future research.
AB - Lipids perform a wide range of functions inside the cell, ranging from structural building block of membranes and energy storage to cell signaling. The mode of action of many signaling lipids has remained elusive due to their low abundance, high lipophilicity, and inherent instability. Various chemical biology approaches, such as photoaffinity or activity-based protein profiling methods, have been employed to shed light on the biological role of lipids and the lipid–protein interaction profile. In this review, we will summarize the recent developments in the field of chemical probes to study lipid biology, especially in immunology, and indicate potential avenues for future research.
UR - https://www.scopus.com/pages/publications/85060535932
U2 - 10.1007/82_2018_127
DO - 10.1007/82_2018_127
M3 - Chapter
C2 - 30242513
T3 - Current Topics in Microbiology and Immunology
SP - 283
EP - 319
BT - Current Topics in Microbiology and Immunology
PB - Springer Verlag
ER -