Novel targets for prevention and inhibition of proliferation and metastasis of esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) is a highly malignant disease with a dismal prognosis. In the Western world, EAC presents a growing number of new cases, which poses a health challenge in recent years. Novel molecular treatments to improve patients’ outcomes are an unmet medical need. Barrett’s esophagus (BE) is a metaplastic condition that predisposes for EAC. Non-dysplastic BE