Novel molecular and cellular mechanisms of genetic arrhythmogenic disease Insights into the pathobiology of TNNI3K and HCN4

Synchronized beating and proper contraction of the heart is essential for efficient blood flow through the body. These physiological processes can be affected by genetic cardiac disorders. Since the rapid rise in genetic sequencing methods, there has been a strong increase in identification of genetic variants and disease-related genes. The molecular disease mechanisms of many genetic variants, and genetic cardiac disorders are still not well understood.